Re: Testicular cancerOn Apr 10, 8:41 am, usen...@gmail,com wrote:stop and/or cure
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Curr Med Chem 2003 Jun;10(12):1021-34
The role of iron chelation in cancer therapy.
Buss JL, Torti FM, Torti SV
Drug Discovery Chemistry, Actelion Pharmaceuticals Ltd.,
Gewerbestrasse 16,
CH-4123 Allschwil / BL, Switzerland. christoph.b...@actelion,com and
christoph.bink...@actelion,com
[Medline record in process]
This review focuses on advances and strategies in the use of iron
chelators as
anti-tumor therapies. Although the development of iron chelators for
human
disease has focused primarily on their use in the treatment of
secondary iron
overload, chelators may also be useful anti-tumor agents. They can
deplete iron
or cause oxidative stress in the tumor due to redox perturbations in
its
environment. Iron chelators have been tested for their anti-tumor
activity in
cell culture experiments, animal models and human clinical trials.
Largely for
pragmatic reasons, clinical studies of the anti-tumor activity of
iron
chelators have generally focused on desferrioxamine (DFO), a drug
approved for
the treatment of iron overload. These studies have shown that DFO can
retard
tumor growth in many different experimental contexts. However, the
activity of
DFO is modest, and advances in the use of chelators as anti-cancer
agents will
require the development of new chelators based on new paradigms.
Examples of
iron chelators that have shown promising anti-tumor activity (in
various stages
of development) include heterocyclic carboxaldehyde
thiosemicarbazones, analogs
of pyridoxal isonicotinoyl hydrazone, tachpyridine, O-trensox,
desferrithiocin,
and other natural and synthetic chelators. Apart from their use as
single
agents, chelators may also synergize with other anti-cancer therapies.
The
development of chelators as anticancer agents is largely an unexplored
field,
but one with extraordinary potential to impact human cancer.
PMID: 12678674, UI: 22565600
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