Group: sci.med.nutrition

Physiological impacts of diet.

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AKBA counteracts LTB4 from AA overload

Reply from: Taka
Date: 11 Apr 2008, 10:07
AKBA counteracts LTB4 from AA overload

A better approach would be to replace arachidonic acid (AA) with the
Mead acid but that is a long way to go especially for those who got
cancer and carry a lot of Omega-6 in their body fat stores:

QUOTE: While the polyunsaturated fats known as omega-6 fatty acids are
essential to optimal health, most Americans and citizens of other
Western nations consume far too many omega-6 polyunsaturated fatty
acids and not enough omega-3 polyunsaturated fatty acids. In fact,
some Western diets consists of 20 parts of omega-6 to only one part of
omega-3. For optimum health, the ratio of omega-6 to omega-3 fatty
acids should be between 1:1 and 4:1. This severe imbalance that occurs
with most people contributes to the development of long-term health
problems.
...
The typical American diet is loaded with foods that contain
arachidonic acid (like egg yolk, red meat, poultry, and dairy
products) or stimulate the production of excess arachidonic acid in
the body (foods rich in high-glyce-mic carbohydrates, saturated fats,
and omega-6 fatty acids).

Scientific studies show that excess arachidonic acid increases levels
of the 5-lipoxy-genase (5-LOX) enzyme, which can induce undesirable
effects in cells.* This culminates in the excess accumulation of leu-
kotriene B4 (LTB4), a pro-inflammatory compound that attacks the
joints, the arterial wall, and other tissues.

In India, extracts from the Boswellia plant have been used for
centuries as fluid balancing agents. Recent human studies have
confirmed that a specific Boswellia extract known as AKBA (3-O-
acetyl-11-keto-ß-boswellic acid) selectively inhibits 5-LOX. Unlike
other boswellic acids that only partially inhibit 5-LOX, AKBA binds
directly to 5-LOX, effectively suppressing its pro-inflam-matory
activity. UNQUOTE.

SOURCE:
http :// www .lef.org/newshop/items/item00939.html?source=eNewsLetter2008Wk15-2&key=Body+Product

Taka




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