Leg Ulcers and Multiple Sclerosis

Leg Ulcers and Multiple Sclerosis

"Iron chelators against venous leg ulcers and multiple sclerosis"

Hypothetical molecular mechanisms by which local iron overload
facilitates the development of venous leg ulcers and multiple
sclerosis lesions. [JOURNAL ARTICLE]
Med Hypotheses 2008 Apr 7.
Simka M, Rybak Z

This paper presents a hypothetical model of role for iron in the
development of venous leg ulcers and multiple sclerosis.
Elevated concentrations of iron were found in the skin affected by
venous hypertension and also in the areas of brain with multiple
sclerosis lesions.
Individuals with hemochromatosis gene (HFE) mutations: C282Y and H63D,
which result in a less efficient transport of iron by macrophages, are
characterized by an increased risk for venous leg ulcer and multiple
sclerosis.
Multiple sclerosis is a T cell-mediated disease, and T cells probably
participate in the development of venous ulcers.
This deleterious role of ferric ions could be related to the
regulation of T cell proliferation and apoptosis.
Under normal conditions excessive accumulation of T cells cannot take
place, because nitric oxide and interferon-gamma drive these cells
toward apoptosis.
However, in tissues with a high concentration of iron, T lymphocytes
proliferate instead of undergoing apoptosis.
This is possible due to the internalization of the INF-gammaR2 chain
of the interferon-gamma receptor, the downregulation of inducible
nitric oxide synthase expression in macrophages and the inactivation
of the active site of caspases.
Yet, it should be emphasized that this hypothesis does not claim for
the increased concentration of iron as a direct causal factor for the
development of venous ulcerations or multiple sclerosis, but rather,
iron is a factor that modulates and exaggerates the autoimmune
process.
Iron chelators, administered systemically or locally, should
potentially exhibit therapeutic and prophylactic activity against
venous leg ulcers and multiple sclerosis.
Medical hypotheses [Med Hypotheses]
--------------------------------------------------------------------------------

Who loves ya.
Tom


Jesus Was A Vegetarian!
http :// tinyurl,com /2r2nkh


Man Is A Herbivore!
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DEAD PEOPLE WALKING
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Re: Leg Ulcers and Multiple Sclerosis

YAWN

Your bore me Tommy Tit.

Your copy and pastes look ugly...never read them and
you are full of Tit Shit...
(It's raining ...this is me being nice to you)

Now go and amuse yourself elsewhere..

--
Dora
Dangerous with Attitude

I do it cause I can
"ironjustice" <teamtanner@hotmail,com > wrote in message
news:9b2ef251-8035-49a1-a378-fdee00ed9410@n14g2000pri.googlegroups,com ...
> "Iron chelators against venous leg ulcers and multiple sclerosis"
>
> Hypothetical molecular mechanisms by which local iron overload
> facilitates the development of venous leg ulcers and multiple
> sclerosis lesions. [JOURNAL ARTICLE]
> Med Hypotheses 2008 Apr 7.
> Simka M, Rybak Z
>
> This paper presents a hypothetical model of role for iron in the
> development of venous leg ulcers and multiple sclerosis.
> Elevated concentrations of iron were found in the skin affected by
> venous hypertension and also in the areas of brain with multiple
> sclerosis lesions.
> Individuals with hemochromatosis gene (HFE) mutations: C282Y and H63D,
> which result in a less efficient transport of iron by macrophages, are
> characterized by an increased risk for venous leg ulcer and multiple
> sclerosis.
> Multiple sclerosis is a T cell-mediated disease, and T cells probably
> participate in the development of venous ulcers.
> This deleterious role of ferric ions could be related to the
> regulation of T cell proliferation and apoptosis.
> Under normal conditions excessive accumulation of T cells cannot take
> place, because nitric oxide and interferon-gamma drive these cells
> toward apoptosis.
> However, in tissues with a high concentration of iron, T lymphocytes
> proliferate instead of undergoing apoptosis.
> This is possible due to the internalization of the INF-gammaR2 chain
> of the interferon-gamma receptor, the downregulation of inducible
> nitric oxide synthase expression in macrophages and the inactivation
> of the active site of caspases.
> Yet, it should be emphasized that this hypothesis does not claim for
> the increased concentration of iron as a direct causal factor for the
> development of venous ulcerations or multiple sclerosis, but rather,
> iron is a factor that modulates and exaggerates the autoimmune
> process.
> Iron chelators, administered systemically or locally, should
> potentially exhibit therapeutic and prophylactic activity against
> venous leg ulcers and multiple sclerosis.
> Medical hypotheses [Med Hypotheses]
> --------------------------------------------------------------------------------
>
> Who loves ya.
> Tom
>
>
> Jesus Was A Vegetarian!
> http :// tinyurl,com /2r2nkh
>
>
> Man Is A Herbivore!
> http :// tinyurl,com /a3cc3
>
>
> DEAD PEOPLE WALKING
> http :// tinyurl,com /zk9fk
>
>

Re: Leg Ulcers and Multiple Sclerosis

On Apr 13, 9:05 am, "Dangerous" <danger...@telus,net > wrote:you are
full of Tit Shit <<

Over the years .. one can do an epidemiological study of what groups
are actually .. contributive ..

Karma .. comes to .. mind ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http :// tinyurl,com /2r2nkh


Man Is A Herbivore!
http :// tinyurl,com /a3cc3


DEAD PEOPLE WALKING
http :// tinyurl,com /zk9fk




> YAWN
>
>   Your bore me Tommy Tit.
>
> Your copy and pastes  look ugly...never read them and
> you are full of Tit Shit...
> (It's raining ...this is me being nice to you)
>
> Now go and amuse yourself elsewhere..
>
> --
> Dora
> Dangerous with Attitude
>
> I do it cause I can"ironjustice" <teamtan...@hotmail,com > wrote in message
>
> news:9b2ef251-8035-49a1-a378-fdee00ed9410@n14g2000pri.googlegroups,com ...
>
>
>
> > "Iron chelators against venous leg ulcers and multiple sclerosis"
>
> > Hypothetical molecular mechanisms by which local iron overload
> > facilitates the development of venous leg ulcers and multiple
> > sclerosis lesions. [JOURNAL ARTICLE]
> > Med Hypotheses 2008 Apr 7.
> > Simka M, Rybak Z
>
> > This paper presents a hypothetical model of role for iron in the
> > development of venous leg ulcers and multiple sclerosis.
> > Elevated concentrations of iron were found in the skin affected by
> > venous hypertension and also in the areas of brain with multiple
> > sclerosis lesions.
> > Individuals with hemochromatosis gene (HFE) mutations: C282Y and H63D,
> > which result in a less efficient transport of iron by macrophages, are
> > characterized by an increased risk for venous leg ulcer and multiple
> > sclerosis.
> > Multiple sclerosis is a T cell-mediated disease, and T cells probably
> > participate in the development of venous ulcers.
> > This deleterious role of ferric ions could be related to the
> > regulation of T cell proliferation and apoptosis.
> > Under normal conditions excessive accumulation of T cells cannot take
> > place, because nitric oxide and interferon-gamma drive these cells
> > toward apoptosis.
> > However, in tissues with a high concentration of iron, T lymphocytes
> > proliferate instead of undergoing apoptosis.
> > This is possible due to the internalization of the INF-gammaR2 chain
> > of the interferon-gamma receptor, the downregulation of inducible
> > nitric oxide synthase expression in macrophages and the inactivation
> > of the active site of caspases.
> > Yet, it should be emphasized that this hypothesis does not claim for
> > the increased concentration of iron as a direct causal factor for the
> > development of venous ulcerations or multiple sclerosis, but rather,
> > iron is a factor that modulates and exaggerates the autoimmune
> > process.
> > Iron chelators, administered systemically or locally, should
> > potentially exhibit therapeutic and prophylactic activity against
> > venous leg ulcers and multiple sclerosis.
> > Medical hypotheses [Med Hypotheses]
> > ---------------------------------------------------------------------------­-----
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian!
> > http :// tinyurl,com /2r2nkh
>
> > Man Is A Herbivore!
> > http :// tinyurl,com /a3cc3
>
> > DEAD PEOPLE WALKING
> > http :// tinyurl,com /zk9fk- Hide quoted text -
>
> - Show quoted text -

Re: Leg Ulcers and Multiple Sclerosis

If a vote were taken...you would be gone .

--
Dora
Dangerous with Attitude

I do it cause I can
"ironjustice" <teamtanner@hotmail,com > wrote in message
news:23293316-2991-47b1-ba8b-b740d6c73e76@k10g2000prm.googlegroups,com ...
On Apr 13, 9:05 am, "Dangerous" <danger...@telus,net > wrote:you are
full of Tit Shit <<

Over the years .. one can do an epidemiological study of what groups
are actually .. contributive ..

Karma .. comes to .. mind ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http :// tinyurl,com /2r2nkh


Man Is A Herbivore!
http :// tinyurl,com /a3cc3


DEAD PEOPLE WALKING
http :// tinyurl,com /zk9fk




> YAWN
>
> Your bore me Tommy Tit.
>
> Your copy and pastes look ugly...never read them and
> you are full of Tit Shit...
> (It's raining ...this is me being nice to you)
>
> Now go and amuse yourself elsewhere..
>
> --
> Dora
> Dangerous with Attitude
>
> I do it cause I can"ironjustice" <teamtan...@hotmail,com > wrote in message
>
> news:9b2ef251-8035-49a1-a378-fdee00ed9410@n14g2000pri.googlegroups,com ...
>
>
>
> > "Iron chelators against venous leg ulcers and multiple sclerosis"
>
> > Hypothetical molecular mechanisms by which local iron overload
> > facilitates the development of venous leg ulcers and multiple
> > sclerosis lesions. [JOURNAL ARTICLE]
> > Med Hypotheses 2008 Apr 7.
> > Simka M, Rybak Z
>
> > This paper presents a hypothetical model of role for iron in the
> > development of venous leg ulcers and multiple sclerosis.
> > Elevated concentrations of iron were found in the skin affected by
> > venous hypertension and also in the areas of brain with multiple
> > sclerosis lesions.
> > Individuals with hemochromatosis gene (HFE) mutations: C282Y and H63D,
> > which result in a less efficient transport of iron by macrophages, are
> > characterized by an increased risk for venous leg ulcer and multiple
> > sclerosis.
> > Multiple sclerosis is a T cell-mediated disease, and T cells probably
> > participate in the development of venous ulcers.
> > This deleterious role of ferric ions could be related to the
> > regulation of T cell proliferation and apoptosis.
> > Under normal conditions excessive accumulation of T cells cannot take
> > place, because nitric oxide and interferon-gamma drive these cells
> > toward apoptosis.
> > However, in tissues with a high concentration of iron, T lymphocytes
> > proliferate instead of undergoing apoptosis.
> > This is possible due to the internalization of the INF-gammaR2 chain
> > of the interferon-gamma receptor, the downregulation of inducible
> > nitric oxide synthase expression in macrophages and the inactivation
> > of the active site of caspases.
> > Yet, it should be emphasized that this hypothesis does not claim for
> > the increased concentration of iron as a direct causal factor for the
> > development of venous ulcerations or multiple sclerosis, but rather,
> > iron is a factor that modulates and exaggerates the autoimmune
> > process.
> > Iron chelators, administered systemically or locally, should
> > potentially exhibit therapeutic and prophylactic activity against
> > venous leg ulcers and multiple sclerosis.
> > Medical hypotheses [Med Hypotheses]
> > ---------------------------------------------------------------------------­-----
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian!
> > http :// tinyurl,com /2r2nkh
>
> > Man Is A Herbivore!
> > http :// tinyurl,com /a3cc3
>
> > DEAD PEOPLE WALKING
> > http :// tinyurl,com /zk9fk- Hide quoted text -
>
> - Show quoted text -