Re: Carbohydrate Alleviates FatigueOn Apr 15, 8:53 am, ironjustice <teamtan...@hotmail,com > wrote:
phosphate <<
Curious how iron ingestion depletes phosphorus and hormones.
"Ferric salts decrease net intestinal phosphate absorption"
"Decreased serum phosphorus and parathyroid hormone concentrations"
J Am Soc Nephrol 10:1274-1280, 1999
© 1999 American Society of Nephrology
--------------------------------------------------------------------------------
REGULAR ARTICLES
New Phosphate Binding Agents
Ferric Compounds
CHEN H. HSU, SANJEEVKUMAR R. PATEL and ERIC W. YOUNG
Nephrology Division, Department of Internal Medicine, University of
Michigan Medical School, VA Medical Center, Ann Arbor, Michigan.
Correspondence to Dr. Chen H. Hsu, 3914 Taubman Center, Nephrology
Division, University Hospital, Ann Arbor, MI 48109-0364. Phone:
313-936-9480; Fax: 313-936-9621; E-mail: hsuc@umich.edu
Abstract. Several prior studies suggest that ferric compounds bind
dietary phosphate and possess clinical potential as phosphate binding
agents. Therefore, this study was conducted to measure the effect of
several ferric compounds on intestinal phosphate binding and
absorption. Balance studies lasting 2 to 4 wk were performed in normal
and azotemic (achieved by subtotal nephrectomy) rats maintained on a
1.02% phosphorus diet supplemented with ferric salts (formulated to
0.95% Fe) or no ferric salt (control). In rats with normal renal
function (average creatinine clearance, 4.0 ml/min per kg), the
average net intestinal absorption of phosphate over all balance
periods was 103.3 mg/d for the control group versus 84.7 mg/d for the
ferric citrate group (P < 0.005). In the azotemic rats (average
creatinine clearance, 3.3 ml/min per kg), the average net intestinal
absorption of phosphate over all balance periods was significantly
lower for the three ferric groups than the control groups (P 0.02):
95.3 mg/d for the control group versus 75.6 mg/d for the ferric
ammonium citrate-treated group (P = 0.058), 77.0 mg/d for the ferric
citrate-treated group (P = 0.057), and 62.5 mg/d for the ferric
chloride-treated group (P < 0.002). Urinary phosphate excretion fell,
sometimes to an even greater extent than did intestinal absorption,
yielding no net reduction in phosphate balance in these growing, young
animals with relatively preserved renal function. Calcium balance was
largely unaffected by the ferric compounds. There were trends toward
decreased serum phosphorus and parathyroid hormone concentrations and
increased iron and hematocrit in the ferric-treated azotemic groups.
All tested ferric compounds were well tolerated, but animal growth was
stunted in the ferric chloride animals compared with the control
group. Phosphate binding was estimated at 85 to 180 mg per gram of
elemental iron, which is comparable to other phosphate binding agents.
Ferric salts decrease net intestinal phosphate absorption and hold
promise for the treatment of phosphate retention in patients with
renal failure.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http :// tinyurl,com /2r2nkh
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http :// tinyurl,com /a3cc3
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> On Apr 15, 7:59 am, ironjustice <teamtan...@hotmail,com >
> wrote:phosphate <<
>
> High altitude is a human model of iron overload in that it causes
> erythrocytosis / increased red blood cell production.
> Coincidentally .. fatigue .. is ,, relieved .. by phosphates.
>
> "Phosphate supplementation"
>
> Effect of phosphate supplementation on oxygen delivery at high
> altitude
> Journal International Journal of Biometeorology
> Publisher Springer Berlin / Heidelberg
> ISSN 0020-7128 (Print) 1432-1254 (Online)
> Issue Volume 31, Number 3 / September, 1987
> DOI 10.1007/BF02188928
> Pages 249-257
> Subject Collection Biomedical and Life Sciences
> SpringerLink Date Friday, September 30, 2005
>
> Effect of phosphate supplementation on oxygen delivery at high
> altitude
> S. C. Jain1, M. V. Singh1, S. B. Rawal1, V. M. Sharma1, H. M.
> Divekar1, A. K. Tyagi1, M. R. Panwar1 and Y. V. Swamy2
>
> (1) Defence Institute of Physiology and Allied Sciences, 110010 Delhi
> Cantt, India
> (2) Naval Science and Technological Lab., 530006 Vishakapatnam,
> India
>
> Received: 31 July 1985
>
> Abstract
> In the present communication, effect of low doses of phosphate
> supplementation on short-term high altitude adaptation has been
> examined.
> Studies were carried out in 36 healthy, male, sea-level residents
> divided in a double blind fashion into drug and placebo treated
> groups. 3.2 mmol of phosphate were given orally to each subject of the
> drug treated group once a day for 4 days on arrival at an altitude of
> 3,500 m.
> Sequential studies were done in the subjects in both groups on the
> 3rd, 7th, 14th and 21st day of their altitude stay.
> Haemoglobin, haematocrit, erythrocyte and reticulocyte counts
> increased to the similar extent in both groups.
> Blood pH, pO2 and adenosine tri-phosphate (ATP) did not differ between
> the two groups.
> On 3rd day of the altitude stay, inorganic phosphate and 2,3-
> diphosphoglycerate (2,3 DPG) levels in the drug treated group
> increased significantly as compared to the placebo group.
> No significant difference in inorganic phosphate and 2,3 DPG was
> observed later on in the two groups.
> Psychological and clinical tests also indicated that the drug treated
> subjects felt better as compared to the placebo treated subjects.
> The present study suggests that low doses of phosphate increases
> circulating 2,3-DPG concentration which in turn brings about
> beneficial effect towards short term high altitude adaptation.
>
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>
>
> > On Apr 14, 5:03 pm, TC <tunder...@hotmail,com > wrote:20 g of carbs is
> > less than the Atkins much maligned 2 week induction <<
>
> > That went over my head ..
> > This article said .. PRE-**exercise** .. so I don't know whether this
> > relates to what you said .. ?
> > Doesn't it say .. load some carbs before exercise .. ?
>
> > "Protection by increasing pre-exercise carbohydrate ingestion"
>
> > What does Atkin's have to do with that .. ?
>
> > I'm missing something ..
>
> > Does Atkins allow for more glucose to be used .. ?
>
> > I might be more inclined to believe the hemolysis caused by exercise
> > is offset by the increased phosphate / remediation INDUCED by the
> > carbohydrate.
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian! http :// tinyurl,com /2r2nkh
>
> > Man Is A Herbivore! http :// tinyurl,com /a3cc3
>
> > DEAD PEOPLE WALKING http :// tinyurl,com /zk9fk
>
> > > On Apr 14, 6:39 pm, "ironjust...@aol,com " <ironjust...@aol,com > wrote:
>
> > > > Pediatr Neurol. 2008 Feb ;38 (2):133-136 18206796 (P,S,E,B,D) One-Year
> > > > Follow-Up in a Child With McArdle Disease: Exercise is Medicine.
>
> > > > [My paper] Margarita Pérez, Carl Foster, Marta González-Freire,
> > > > Joaquín Arenas, Alejandro Lucia
> > > > Department of Exercise Physiology, Universidad Europea de Madrid,
> > > > Madrid, Spain.
> > > > A 9-year-old boy with McArdle disease, who demonstrated remarkable
> > > > recovery of objectively measured exercise tolerance after 1 year of
> > > > follow-up, during which he pursued age-appropriate physical
> > > > activities. The patient presented 1 year previously with severe
> > > > myalgia, muscle weakness, proteinuria, hematuria, hyperthermia, and
> > > > elevated creatine kinase levels after noncompetitive swimming. At that
> > > > time, he reported a 3-year history of general myalgia and poor
> > > > exercise tolerance. He was diagnosed with McArdle disease by both
> > > > biochemical and genetic methods. Subsequently he performed a maximal
> > > > exercise test and was prescribed a return to age-appropriate physical
> > > > activity (protected by a pre-exercise dietary consumption of
> > > > approximately 20 g carbohydrate). At 1-year follow up, he reported no
> > > > subsequent acute clinical episodes, no general problems with exercise
> > > > either at school or in ordinary activities, a virtual normalization of
> > > > serum creatine kinase levels, and a 14% increase in body mass-adjusted
> > > > peak oxygen uptake (from 18.8 to 21.8 mL O(2)/kg/min). The results
> > > > suggest that, with protection by increasing pre-exercise blood glucose
> > > > with carbohydrate ingestion, a substantially normal lifestyle may be
> > > > possible in some children with McArdle disease.
>
> > > > Who loves ya.
> > > > Tom
>
> > > > Jesus Was A Vegetarian! http :// tinyurl,com /2r2nkh
>
> > > > Man Is A Herbivore! http :// tinyurl,com /a3cc3
>
> > > > DEAD PEOPLE WALKING http :// tinyurl,com /zk9fk
>
> > > 20 g of carbs is less than the Atkins much maligned 2 week induction.- Hide quoted text -
>
> > > - Show quoted text -- Hide quoted text -
>
> > - Show quoted text -- Hide quoted text -
>
> - Show quoted text -