Increased Iron and Gestational DiabetesI guess this goes right along with the 'iron deficient women don't get
gestational diabetes'.
"The role of iron excess in the pathogenesis of gestational diabetes
mellitus needs to be examined."
Iron status in women with and without gestational diabetes mellitus.
J Diabetes Complications 2008 Jan 4.
Afkhami-Ardekani M, Rashidi M
OBJECTIVE: Gestational diabetes mellitus (GDM) affects approximately
7% of all pregnancies. Pregnancy, mostly because of the mitochondria-
rich placenta, is a condition that favors oxidative stress. A
transitional metal, especially iron, which is particularly abundant in
the placenta, is important in the production of free radicals. Also,
studies have shown that free radicals have a role in GDM. As there are
little data about iron status in GDM, this study was performed to
compare iron status in GDM and control group.
RESEARCH DESIGN AND METHODS: In this case-control study, 34 women with
diagnosed GDM were compared with 34 non-GDM women in the control group
at 24-28 weeks of pregnancy in terms of iron status, including
ferritin, serum iron, total iron-binding capacity (TIBC), hemoglobin
(Hb), mean corpuscular volume (MCV), and mean corpuscular hemoglobin
(MCH).
RESULTS: In this study, concentration of serum ferritin, iron,
transferrin saturation and hemoglobin, MCV, and MCH was significantly
higher in the GDM group and TIBC was significantly lower in this group
(P<.05). No significant association was observed with the other
variables including familial history of diabetes and GDM.
CONCLUSION: Our findings indicate an association between increased
iron status and GDM. The role of iron excess from iron supplementation
in the pathogenesis of GDM needs to be examined.
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