Re: Homeopathetically SpeakingOn Apr 18, 2:20=A0pm, "ironjust...@aol . com " <ironjust...@aol . com > wrote:
linalool <<
"Linalool up to 1000 mg/kg/day."
Evaluation of the Developmental Toxicity of Linalool in Rats
Authors: Valerie T. Politano a; Elise M. Lewis b; Alan M. Hoberman
b; Mildred S. Christian c; Robert M. Diener c; Anne Marie Api a
Affiliations: a Research Institute for Fragrance Materials, Inc.,
Woodcliff Lake, New Jersey, USA
b Charles River Laboratories Preclinical Services, Horsham,
Pennsylvania, USA
c Argus International, Inc., Horsham, Pennsylvania, USA
DOI: 10.1080/10915810801977948
Publication Frequency: 6 issues per year
Published in: International Journal of Toxicology, Volume 27, Issue 2
March 2008 , pages 183 - 188
Subject: Toxicology;
Formats available: HTML (English) : PDF (English)
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Abstract
The developmental toxicity of linalool, a widely used fragrance
ingredient, was evaluated in presumed pregnant Sprague-Dawley rats (25/
group). Oral dosages of 0, 250, 500, or 1000 mg/kg/day linalool were
administered by gavage on gestational days 7 to 17. The presence of
spermatozoa and/or a copulatory plug in situ was designated as
gestational day 0. Rats were observed for viability, clinical signs,
body weights, and feed consumption. Caesarean sectioning and necropsy
occurred on gestational day 21. Uteri were examined for number and
distribution of implantations, live and dead fetuses, and early and
late resorptions. Numbers of corpora lutea were also recorded. Fetuses
were weighed and examined for gender, gross external changes, and soft
tissue or skeletal alterations. There were no maternal deaths,
clinical signs, or gross lesions that were considered related to
linalool. During the dosage period, mean relative feed consumption was
significantly reduced by 7% and mean body weight gains were reduced by
11% at 1000 mg/kg/day. During the postdosage period, feed consumption
values at 1000 mg/kg/day were significantly higher than vehicle
control values, which corresponded to the increase in body weight
gains during this period. Caesarean section and litter parameters, as
well as fetal alterations, were not affected by linalool at any of the
three dosages tested. On the basis of these data, the maternal no
observed adverse effect level (NOAEL) of linalool is 500 mg/kg/day,
whereas the developmental NOAEL is 1000 mg/kg/day. It is concluded
that linalool is not a developmental toxicant in rats at maternal
doses of up to 1000 mg/kg/day.
Keywords: CAS No. 78-70-6; Developmental Toxicity; Fragrance;
Linalool; Rat
"Neither the crude essential oil nor the purified linalool fraction is
toxic to mammalian cells"
Antimicrobial activity of Croton cajucara Benth linalool-rich
essential oil on artificial biofilms and planktonic microorganisms
Authors: W. S. Alviano1; R. R. Mendon=E7a-Filho; D. S. Alviano2; H. R.
Bizzo3; T. Souto-Padr=F3n2; M. L. Rodrigues2; A. M. Bolognese1; C. S.
Alviano2; M. M. G. Souza1
Oral Microbiol Immunol 2005: 20: 101=96105. =A9 Blackwell Munksgaard,
2005.
We have previously demonstrated that a linalool-rich essential oil
from Croton cajucara Benth presents leishmanicidal activity.
In the present study, we demonstrate that this essential oil inhibits
the growth of reference samples of Candida albicans, Lactobacillus
casei, Staphylococcus aureus, Streptococcus sobrinus, Porphyromonas
gingivalis and Streptococcus mutans cell suspensions, all of them
associated with oral cavity disease.
The purified linalool fraction was only inhibitory for C. albicans.
Microbes of saliva specimens from human individuals with fixed
orthodontic appliances, as well as the reference strains, were used to
construct an artificial biofilm which was exposed to linalool or to
the essential oil.
As in microbial suspensions, the essential oil was toxic for all the
microorganisms, while the purified linalool fraction mainly inhibited
the growth of C. albicans.
The compounds of the essential oil were separated by thin layer
chromatography and exposed to the above-cited microorganisms.
In this analysis, the proliferation of the bacterial cells was
inhibited by still uncharacterized molecules, and linalool was
confirmed as the antifungal component of the essential oil.
The effects of linalool on the cell biology of C. albicans were
evaluated by electron microscopy, which showed that linalool induced a
reduction in cell size and abnormal germination.
Neither the crude essential oil nor the purified linalool fraction is
toxic to mammalian cells, which suggests that the essential oil or its
purified components may be useful to control the microbial population
in patients with fixed orthodontic appliances.
Keywords: antimicrobial activity; Candida albicans; Croton cajucara
Benth; essential oil; linalool; oral microorganisms
Who loves ya.
Tom
Jesus Was A Vegetarian!
* tinyurl . com /2r2nkh
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* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
> On Apr 18, 2:12=A0pm, "ironjust...@aol . com " <ironjust...@aol . com >
> wrote:limonene and linalool <<
>
> Hmm .. there's that .. olfactory .. route .. again ..
> Blood brain barrier .. ?
>
> =A0J Clin Psychiatry. 2002 Jul;63(7):553-8.Related Articles, Links
> Comment in:
> J Clin Psychiatry. 2003 Jun;64(6):732; author reply 732.
>
> Aromatherapy as a safe and effective treatment for the management of
> agitation in severe dementia: the results of a double-blind, placebo-
> controlled trial with Melissa.
>
> Ballard CG, O'Brien JT, Reichelt K, Perry EK.
>
> Wolfson Research Centre, Newcastle General Hospital, Institute for
> Ageing and Health, Newcastle upon Tyne, United Kingdom.
> c.g.ball...@ncl.ac.uk
>
> BACKGROUND: Behavioral and psychological symptoms in dementia are
> frequent and are a major management problem, especially for patients
> with severe cognitive impairment. Preliminary reports have indicated
> positive effects of aromatherapy using select essential oils, but
> there are no adequately powered placebo-controlled trials. We
> conducted a placebo-controlled trial to determine the value of
> aromatherapy with essential oil of Melissa officinalis (lemon balm)
> for agitation in people with severe dementia. METHOD: Seventy-two
> people residing in National Health Service (U.K.) care facilities who
> had clinically significant agitation in the context of severe dementia
> were randomly assigned to aromatherapy with Melissa essential oil (N =3D
> 36) or placebo (sunflower oil) (N =3D 36). The active treatment or
> placebo oil was combined with a base lotion and applied to patients'
> faces and arms twice a day by caregiving staff. Changes in clinically
> significant agitation (Cohen-Mansfield Agitation Inventory [CMAI]) and
> quality of life indices (percentage of time spent socially withdrawn
> and percentage of time engaged in constructive activities, measured
> with Dementia Care Mapping) were compared between the 2 groups over a
> 4-week period of treatment. RESULTS: Seventy-one patients completed
> the trial. No significant side effects were observed. Sixty percent
> (21/35) of the active treatment group and 14% (5/36) of the placebo-
> treated group experienced a 30% reduction of CMAI score, with an
> overall improvement in agitation (mean reduction in CMAI score) of 35%
> in patients receiving Melissa balm essential oil and 11% in those
> treated with placebo (Mann-Whitney U test; Z =3D 4.1, p < .0001).
> Quality of life indices also improved significantly more in people
> receiving essential balm oil (Mann-Whitney U test; percentage of time
> spent socially withdrawn: Z =3D 2.6, p =3D .005; percentage of time
> engaged in constructive activities: Z =3D 3.5, p =3D .001). CONCLUSION:
> The finding that aromatherapy with essential balm oil is a safe and
> effective treatment for clinically significant agitation in people
> with severe dementia, with additional benefits for key quality of life
> parameters, indicates the need for further controlled trials.
>
> Publication Types:
> Clinical Trial
> Randomized Controlled Trial
>
> PMID: 12143909 [PubMed - indexed for MEDLINE]
>
> --------------------------------------------------------------------------=
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>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! * tinyurl . com /2r2nkh
>
> Man Is A Herbivore! * tinyurl . com /a3cc3
>
> DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
>
>
> > On Apr 18, 1:10=A0pm, "ironjust...@aol . com " <ironjust...@aol . com >
> > wrote:Limonene and Linalool <<
>
> > * tinyurl . com /6r74pr
>
> > Limonene and Linalool - Natural v synthetic
> > A question that often crops up regards the safety of limonene and
> > linalool. There have been lots of scare stories in the press and on
> > the internet which stems from confusion regarding synthetic limonene
> > and linalool and the natural counterparts.
>
> > Limonene and linalool occur naturally as a contituent in many
> > essential oils. For example, one of the natural constituents of lemon
> > essential oil is limonene, and one of the natural constituents of
> > lavender essential oil is linalool.
>
> > They can also be manufactured synthetically and this is where the
> > problems occur. When produced synthetically they can have all sorts of
> > nasty side effects due to the extreme strength at which they are
> > produced, using often aggressive chemicals. On the other hand, Mother
> > Nature is so clever that, when she produces it, she only does it in
> > perfect balance so that when used correctly it is not only safe but
> > beneficial.
>
> > It used to be that the natural componentry of essential oils did not
> > have to be shown on ingredients listings but recent legislation says
> > that manufacturers need to show them. It can be really confusing for
> > customers. What is important is that when you read ingredient labels,
> > you need to check for whether the limonene and linalool are naturally
> > occuring from essential oils contained in the product.
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian! * tinyurl . com /2r2nkh
>
> > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
> > > "Tremors, excess salivation, lack of coordination and muscle weakness"=
>
> > > Limonene and Linalool (Citrus Peel Extracts) - Contain insecticidal
> > > compounds that kill many insect pests, e.g., fire ants, and fleas, but=
> > > may be of low toxicity to mammals. =A0There is some controversy as to
> > > their safety and should, therefore, only be used with discretion and
> > > proper notification. =A0The two most effective insecticidal compounds
> > > are d-limonene, a terpene that constitutes about 90% of crude citrus
> > > oil, and linalool, a terpene alcohol. Terpenes are hydrocarbons found
> > > in essential oils. =A0They are used as solvents, fragrances and flavor=
s
> > > in cosmetics and beverages. =A0Linalool can also be extracted from pin=
e
> > > wood. Citrus oils have a fresh floral odor and an oil consistency.
> > > Limonene and linalool are contact poisons that heighten sensory nerve
> > > activity in insects, causing massive over-stimulation of motor nerves
> > > that leads to convulsion and paralysis. =A0Some insects, such as adult=
> > > fleas, can recover from the initial paralysis unless limonene is
> > > synergized by pipernoyl butoxide (PBO), or formulated with sodium
> > > borate - not done commercially as yet. It has been determined that
> > > linalool is not a cholinesterase inhibitor (a nerve poison), but it is=
> > > when formulated with the questionable pipernoyl butoxide. =A0Limonene
> > > and linalool are available in aerosol and liquid products. =A0They are=
> > > currently marketed primarily as flea dips and shampoos but are also
> > > formulated with insecticidal soap for use as contact poisons. =A0When
> > > applied topically to some laboratory animals both compounds can
> > > irritate the skin, eyes and mucous membranes. Both moderate and high
> > > does of these substances can cause tremors, excess salivation, lack of=
> > > coordination and muscle weakness. =A0However, the symptoms are usually=
> > > temporary, lasting several hours to several days, and the animals
> > > usually recover fully. =A0Limonene has been shown to promote tumor
> > > formation in mouse skin, so use these products sparingly and with
> > > proper notification. =A0Limonene and linalool are currently registered=
> > > for use against fleas, aphids and mites, but, these compounds also
> > > kill fire ants, houseflies, stable flies, black soldier flies, paper
> > > wasps and house crickets. =A0In a field test using grated limes, all t=
he
> > > fruit flies were immobilized in 15 minutes, and all were dead in two
> > > hours. =A0Citrus oils (commercial or homemade), therefore, have the
> > > potential for much wider use, including treatments for livestock and
> > > human ectoparasites, fumigation of food handling and storage
> > > facilities and household pest control.
>
> > > Who loves ya.
> > > Tom
>
> > > Jesus Was A Vegetarian! * tinyurl . com /2r2nkh
>
> > > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > > DEAD PEOPLE WALKING * tinyurl . com /zk9fk-Hide quoted text -
>
> > - Show quoted text -- Hide quoted text -
>
> - Show quoted text -