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Breast Cancer and Green Tea
Breast Cancer and Green Tea
Thank you for your post, Ironjustice
Here's from earlier studies we posted before.
From Health Lover, Ilena Rosenthal.
http :// ilenarose.blogspot,com
Anti-Cancer Compound in Green Tea Identified
Tue Mar 15, 2005 12:13 AM ET
By Patricia Reaney
LONDON (Reuters) - Spanish and British scientists have discovered how
green tea helps to prevent certain types of cancer.
Researchers at the University of Murcia in Spain (UMU) and the John
Innes Center (JIC) in Norwich, England have shown that a compound
called EGCG in green tea prevents cancer cells from growing by binding
to a specific enzyme.
"We have shown for the first time that EGCG, which is present in green
tea at relatively high concentrations, inhibits the enzyme
dihydrofolate reductase (DHFR), which is a recognized, established
target for anti-cancer drugs, " Professor Roger Thorneley, of JIC,
told Reuters.
"This is the first time, to our knowledge, a known target for an
anti-cancer drug has been identified as being inhibited by EGCG," he
added.
Green tea has about five times as much EGCG as regular tea, studies
have shown. It decreased rates of certain cancers but scientists were
not sure what compounds were involved or how they worked. Nor had they
determined how much green tea a person would have to drink to have a
beneficial effect, he said.
Thorneley said EGCG is probably just one of a number of anti-cancer
mechanisms in green tea.
"We have identified this enzyme in tumour cells that EGCG targets and
understand how it stops this enzyme from making DNA. This means we may
be able to develop new anti-cancer drugs based on the structure of the
EGCG molecule," Thorneley explained.
The scientists decided to look at ECGC after they realized its
structure was similar to a cancer drug called methotrexate.
"We discovered that EGCG can kill cancer cells in the same way as
methotrexate," Dr Jose Neptuno Rodriguez-Lopez, of UMU, a joint author
of the research published in the journal Cancer Research.
EGCG binds strongly to DHFR, which is essential in both healthy and
cancerous cells. But it does not bind as tightly as methotrexate, so
its side effects on healthy cells could be less severe than those of
the drug.
Thorneley said EGCG could be a lead compound for new anti-cancer
drugs.
The findings could also explain why women who drink large amounts of
green tea around the time they conceive and early in their pregnancy
may have an increased risk of having a child with spina bifida or
other neural tube disorders.
Women are advised to take supplements of folic acid because it
protects against spina bifida. But large amounts of green tea could
decrease the effectiveness of folic acid.
"This enzyme, (DHFR), is the one folic acid supplements are given for.
Folic acid deficiency leads to neural tube development defects,"
Thorneley added.
Thank you for your post, Ironjustice
Here's from earlier studies we posted before.
From Health Lover, Ilena Rosenthal.
http :// ilenarose.blogspot,com
Anti-Cancer Compound in Green Tea Identified
Tue Mar 15, 2005 12:13 AM ET
By Patricia Reaney
LONDON (Reuters) - Spanish and British scientists have discovered how
green tea helps to prevent certain types of cancer.
Researchers at the University of Murcia in Spain (UMU) and the John
Innes Center (JIC) in Norwich, England have shown that a compound
called EGCG in green tea prevents cancer cells from growing by binding
to a specific enzyme.
"We have shown for the first time that EGCG, which is present in green
tea at relatively high concentrations, inhibits the enzyme
dihydrofolate reductase (DHFR), which is a recognized, established
target for anti-cancer drugs, " Professor Roger Thorneley, of JIC,
told Reuters.
"This is the first time, to our knowledge, a known target for an
anti-cancer drug has been identified as being inhibited by EGCG," he
added.
Green tea has about five times as much EGCG as regular tea, studies
have shown. It decreased rates of certain cancers but scientists were
not sure what compounds were involved or how they worked. Nor had they
determined how much green tea a person would have to drink to have a
beneficial effect, he said.
Thorneley said EGCG is probably just one of a number of anti-cancer
mechanisms in green tea.
"We have identified this enzyme in tumour cells that EGCG targets and
understand how it stops this enzyme from making DNA. This means we may
be able to develop new anti-cancer drugs based on the structure of the
EGCG molecule," Thorneley explained.
The scientists decided to look at ECGC after they realized its
structure was similar to a cancer drug called methotrexate.
"We discovered that EGCG can kill cancer cells in the same way as
methotrexate," Dr Jose Neptuno Rodriguez-Lopez, of UMU, a joint author
of the research published in the journal Cancer Research.
EGCG binds strongly to DHFR, which is essential in both healthy and
cancerous cells. But it does not bind as tightly as methotrexate, so
its side effects on healthy cells could be less severe than those of
the drug.
Thorneley said EGCG could be a lead compound for new anti-cancer
drugs.
The findings could also explain why women who drink large amounts of
green tea around the time they conceive and early in their pregnancy
may have an increased risk of having a child with spina bifida or
other neural tube disorders.
Women are advised to take supplements of folic acid because it
protects against spina bifida. But large amounts of green tea could
decrease the effectiveness of folic acid.
"This enzyme, (DHFR), is the one folic acid supplements are given for.
Folic acid deficiency leads to neural tube development defects,"
Thorneley added.
Re: Breast Cancer and Green Tea
On 20 abr, 12:07, Ilena Rose <B...@mundo,com > wrote:
> Thank you for your post, Ironjustice
>
> Here's from earlier studies we posted before.
> From Health Lover, Ilena Rosenthal. http :// ilenarose.blogspot,com
>
> Anti-Cancer Compound in Green Tea Identified
> Tue Mar 15, 2005 12:13 AM ET
>
> By Patricia Reaney
> LONDON (Reuters) - Spanish and British scientists have discovered how
> green tea helps to prevent certain types of cancer.
>
> Researchers at the University of Murcia in Spain (UMU) and the John
> Innes Center (JIC) in Norwich, England have shown that a compound
> called EGCG in green tea prevents cancer cells from growing by binding
> to a specific enzyme.
>
> "We have shown for the first time that EGCG, which is present in green
> tea at relatively high concentrations, inhibits the enzyme
> dihydrofolate reductase (DHFR), which is a recognized, established
> target for anti-cancer drugs, " Professor Roger Thorneley, of JIC,
> told Reuters.
>
> "This is the first time, to our knowledge, a known target for an
> anti-cancer drug has been identified as being inhibited by EGCG," he
> added.
>
> Green tea has about five times as much EGCG as regular tea, studies
> have shown. It decreased rates of certain cancers but scientists were
> not sure what compounds were involved or how they worked. Nor had they
> determined how much green tea a person would have to drink to have a
> beneficial effect, he said.
>
> Thorneley said EGCG is probably just one of a number of anti-cancer
> mechanisms in green tea.
>
> "We have identified this enzyme in tumour cells that EGCG targets and
> understand how it stops this enzyme from making DNA. This means we may
> be able to develop new anti-cancer drugs based on the structure of the
> EGCG molecule," Thorneley explained.
>
> The scientists decided to look at ECGC after they realized its
> structure was similar to a cancer drug called methotrexate.
>
> "We discovered that EGCG can kill cancer cells in the same way as
> methotrexate," Dr Jose Neptuno Rodriguez-Lopez, of UMU, a joint author
> of the research published in the journal Cancer Research.
>
> EGCG binds strongly to DHFR, which is essential in both healthy and
> cancerous cells. But it does not bind as tightly as methotrexate, so
> its side effects on healthy cells could be less severe than those of
> the drug.
>
> Thorneley said EGCG could be a lead compound for new anti-cancer
> drugs.
>
> The findings could also explain why women who drink large amounts of
> green tea around the time they conceive and early in their pregnancy
> may have an increased risk of having a child with spina bifida or
> other neural tube disorders.
>
> Women are advised to take supplements of folic acid because it
> protects against spina bifida. But large amounts of green tea could
> decrease the effectiveness of folic acid.
>
> "This enzyme, (DHFR), is the one folic acid supplements are given for.
> Folic acid deficiency leads to neural tube development defects,"
> Thorneley added.
As a conclusion, If I understand this posting well it need to be said
that pregnant women need to use a folic acid supplement if they are
drinking a lot of green tea in order to reduce the risk of having a
child with spina bifida or other neural tube disorders.
General care should be taken when you are consuming high quantities of
green tea and even more with green tea extracts. According to recent
published studies ( http :// pubs.acs.org/cgi-bin/sample.cgi/crtoec/
2007/20/i04/html/tx7000515.html), green tea is good for you, but only
if drunk in moderation. The polyphenols in green tea are credited with
preventing heart disease and cancer but higher doses of these
substances can cause liver and kidney damage. "People shouldn't be too
alarmed by this, but those taking supplements may experience
problems," says lead author Chung Yang of Rutgers, the State
University of New Jersey.
He stresses that up to 10 small cups of green tea a day is fine.
Problems are likely in people who take supplements, which can contain
up to 50 times as much polyphenol as a single cup of tea. Yang also
reports cases of people who experienced liver toxicity after
overdosing on green-tea-based supplements. Their symptoms disappeared
when they stopped taking the pills, only to return when they started
taking them again (Chemical Research in Toxicology, vol 20, p 583).
--------------------
Sent via 2ajobguide,com
http :// 2ajobguide,com /x ray jobs medical radiology.aspx
On 20 abr, 12:07, Ilena Rose <B...@mundo,com > wrote:
> Thank you for your post, Ironjustice
>
> Here's from earlier studies we posted before.
> From Health Lover, Ilena Rosenthal. http :// ilenarose.blogspot,com
>
> Anti-Cancer Compound in Green Tea Identified
> Tue Mar 15, 2005 12:13 AM ET
>
> By Patricia Reaney
> LONDON (Reuters) - Spanish and British scientists have discovered how
> green tea helps to prevent certain types of cancer.
>
> Researchers at the University of Murcia in Spain (UMU) and the John
> Innes Center (JIC) in Norwich, England have shown that a compound
> called EGCG in green tea prevents cancer cells from growing by binding
> to a specific enzyme.
>
> "We have shown for the first time that EGCG, which is present in green
> tea at relatively high concentrations, inhibits the enzyme
> dihydrofolate reductase (DHFR), which is a recognized, established
> target for anti-cancer drugs, " Professor Roger Thorneley, of JIC,
> told Reuters.
>
> "This is the first time, to our knowledge, a known target for an
> anti-cancer drug has been identified as being inhibited by EGCG," he
> added.
>
> Green tea has about five times as much EGCG as regular tea, studies
> have shown. It decreased rates of certain cancers but scientists were
> not sure what compounds were involved or how they worked. Nor had they
> determined how much green tea a person would have to drink to have a
> beneficial effect, he said.
>
> Thorneley said EGCG is probably just one of a number of anti-cancer
> mechanisms in green tea.
>
> "We have identified this enzyme in tumour cells that EGCG targets and
> understand how it stops this enzyme from making DNA. This means we may
> be able to develop new anti-cancer drugs based on the structure of the
> EGCG molecule," Thorneley explained.
>
> The scientists decided to look at ECGC after they realized its
> structure was similar to a cancer drug called methotrexate.
>
> "We discovered that EGCG can kill cancer cells in the same way as
> methotrexate," Dr Jose Neptuno Rodriguez-Lopez, of UMU, a joint author
> of the research published in the journal Cancer Research.
>
> EGCG binds strongly to DHFR, which is essential in both healthy and
> cancerous cells. But it does not bind as tightly as methotrexate, so
> its side effects on healthy cells could be less severe than those of
> the drug.
>
> Thorneley said EGCG could be a lead compound for new anti-cancer
> drugs.
>
> The findings could also explain why women who drink large amounts of
> green tea around the time they conceive and early in their pregnancy
> may have an increased risk of having a child with spina bifida or
> other neural tube disorders.
>
> Women are advised to take supplements of folic acid because it
> protects against spina bifida. But large amounts of green tea could
> decrease the effectiveness of folic acid.
>
> "This enzyme, (DHFR), is the one folic acid supplements are given for.
> Folic acid deficiency leads to neural tube development defects,"
> Thorneley added.
As a conclusion, If I understand this posting well it need to be said
that pregnant women need to use a folic acid supplement if they are
drinking a lot of green tea in order to reduce the risk of having a
child with spina bifida or other neural tube disorders.
General care should be taken when you are consuming high quantities of
green tea and even more with green tea extracts. According to recent
published studies ( http :// pubs.acs.org/cgi-bin/sample.cgi/crtoec/
2007/20/i04/html/tx7000515.html), green tea is good for you, but only
if drunk in moderation. The polyphenols in green tea are credited with
preventing heart disease and cancer but higher doses of these
substances can cause liver and kidney damage. "People shouldn't be too
alarmed by this, but those taking supplements may experience
problems," says lead author Chung Yang of Rutgers, the State
University of New Jersey.
He stresses that up to 10 small cups of green tea a day is fine.
Problems are likely in people who take supplements, which can contain
up to 50 times as much polyphenol as a single cup of tea. Yang also
reports cases of people who experienced liver toxicity after
overdosing on green-tea-based supplements. Their symptoms disappeared
when they stopped taking the pills, only to return when they started
taking them again (Chemical Research in Toxicology, vol 20, p 583).
--------------------
Sent via 2ajobguide,com
http :// 2ajobguide,com /x ray jobs medical radiology.aspx
