Kidney Failure and Brain Function

Kidney Failure and Brain Function

"Antioxidants (N-acetylcysteine, NAC and deferoxamine, DFX) prevented
such effect"

Neurosci Lett. 2008 Mar 21;434(1):139-43. Epub 2008 Jan 31. Inhibition
of brain creatine kinase activity after renal ischemia is attenuated
by N-acetylcysteine and deferoxamine administration.
Di-Pietro PB, Dias ML, Scaini G, Burigo M, Constantino L, Machado RA,
Dal-Pizzol F, Streck EL.
Laboratório de Fisiopatologia Experimental, Programa de Pós-graduação
em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde,
Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC,
Brazil.

Encephalopathy may accompany acute or chronic renal failure, and the
mechanisms responsible for neurological complications in patients with
renal failure are poorly known. Considering that creatine kinase (CK)
is important for brain energy homeostasis and is inhibited by free
radicals, and that oxidative stress is probably involved in the
pathogenesis of uremic encephalopathy, we measured CK activity
(hippocampus, striatum, cerebellum, cerebral cortex and prefrontal
cortex) in brain if rats submitted to renal ischemia and the effect of
administration of antioxidants (N-acetylcysteine, NAC and
deferoxamine, DFX) on this enzyme. We verified that CK activity was
not altered in cerebellum and striatum of rats. CK activity was
inhibited in prefrontal cortex and hippocampus of rats 12h after renal
ischemia. The treatment with antioxidants prevented such effect.
Cerebral cortex was also affected, but in this area CK activity was
inhibited 6 and 12h after renal ischemia. Moreover, only NAC or NAC
plus DFX were able to prevent the inhibition on the enzyme. Although
it is difficult to extrapolate our findings to the human condition,
the inhibition of brain CK activity after renal failure may be
associated to neuronal loss and may be involved in the pathogenesis of
uremic encephalopathy.

PMID: 18304734 [PubMed - in process]

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Tom


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Re: Kidney Failure and Brain Function

It would be good if a paragraph or two preceeds this kind of blind
abstract posting. It should tie the contents to some body of research
and/or explanitory model. Otherwise it is only a perverse form of cut
and paste jerking off.

Re: Kidney Failure and Brain Function

On May 2, 6:23 am, pa...@ferris,com wrote:
It would be good if a paragraph or two preceeds this kind of blind
abstract posting.  It should tie the contents to some body of
research
and/or explanitory model.  Otherwise it is only a perverse form of
cut
and paste jerking off. <<

"It is difficult to extrapolate our findings to the human condition"

You agree with the researchers .. then .. ?

Heh .. heh ..

,
"the inhibition of brain CK activity after renal failure may be
associated to neuronal loss"

Understand that .. ?

The **conclusion** of .. that .. ?

"may be involved in the pathogenesis of uremic encephalopathy"

How about .. that .. ?

Understand .. that .. ?

"The treatment with antioxidants prevented such effect"

Now what was the effect .. ?

Bad .. effect .. ?

Brain malfunction .. ?

"Antioxidants"

Now HERE is where you may lose it .. ?

Remembering sht .. ?

"Antioxidants (N-acetylcysteine, NAC and deferoxamine, DFX) prevented
such effect"

Those are **iron** .. **chelators**.

If you understand the .. big picture .. you have no problem .. filing
this in your .. brain ..

Brain ain't working .. ?

You ain't alone .. there .. buddy ..

Glass half full and all ..

Heh .. heh ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http :// tinyurl,com /2r2nkh


Man Is A Herbivore!
http :// tinyurl,com /a3cc3


DEAD PEOPLE WALKING
http :// tinyurl,com /zk9fk