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Pelargonidin
Pelargonidin
Action of pelargonidin on hyperglycemia and oxidative damage in
diabetic rats: Implication for glycation-induced hemoglobin
modification.
Roy M, Sen S, Chakraborti AS
Life Sci 2008 Apr 1.
Glycation-modified hemoglobin in diabetes mellitus has been suggested
to be a source of enhanced catalytic iron and free radicals causing
pathological complications.
The present study aims to verify this idea in experimental diabetes.
Pelargonidin, an anthocyanidin, has been tested for its antidiabetic
potential with emphasis on its role against pathological oxidative
stress including hemoglobin-mediated free radical reactions.
Male wistar rats were grouped as normal control, streptozotocin-
induced diabetic control, normal treated with pelargonidin and
diabetic treated with pelargonidin.
Pelargonidin-treated rats received one time i.p injection of the
flavonoid (3 mg/kg bodyweight).
Biochemical parameters were assayed in blood samples of different
groups of rats.
Liver was used for histological examinations.
Pelargonidin treatment normalized elevated blood glucose levels and
improved serum insulin levels in diabetic rats.
Glucose tolerance test appeared normal after treatment. Decreased
serum levels of SOD and catalase, and increased levels of
malondialdehyde and fructosamine in diabetic rats were reverted to
their respective normal values after pelargonidin administration.
Extents of hemoglobin glycation, hemoglobin-mediated iron release,
iron-mediated free radical reactions and carbonyl formation in
hemoglobin were pronounced in diabetic rats, indicating association
between hemoglobin glycation and oxidative stress in diabetes.
Pelargonidin counteracts hemoglobin glycation, iron release from the
heme protein and iron-mediated oxidative damages, confirming glycated
hemoglobin-associated oxidative stress in diabetes.
Life sciences [Life Sci]
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Anthocyanin
=46rom Wikipedia, the free encyclopedia
Jump to: navigation, search
Anthocyanin gives these pansies their dark purple
pigmentation.Anthocyanins (from Greek: =E1=BC=80=CE=BD=CE=B8=CF=8C=CF=82 (an=
thos) =3D flower +
=CE=BA=CF=85=CE=B1=CE=BD=CF=8C=CF=82 (kyanos) =3D blue) are water-soluble va=
cuolar pigments that may
appear red, purple, or blue, according to pH. The pigment belongs to a
class of molecules called flavonoids, which are synthesized via the
phenylpropanoid pathway. Anthocyanins are synthesized by organisms in
the plant kingdom, and have been observed to occur in all tissues of
higher plants, including leaves, stems, roots, flowers, and fruits.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http :// tinyurl,com /2r2nkh
Man Is A Herbivore!
http :// tinyurl,com /a3cc3
DEAD PEOPLE WALKING
http :// tinyurl,com /zk9fk
Action of pelargonidin on hyperglycemia and oxidative damage in
diabetic rats: Implication for glycation-induced hemoglobin
modification.
Roy M, Sen S, Chakraborti AS
Life Sci 2008 Apr 1.
Glycation-modified hemoglobin in diabetes mellitus has been suggested
to be a source of enhanced catalytic iron and free radicals causing
pathological complications.
The present study aims to verify this idea in experimental diabetes.
Pelargonidin, an anthocyanidin, has been tested for its antidiabetic
potential with emphasis on its role against pathological oxidative
stress including hemoglobin-mediated free radical reactions.
Male wistar rats were grouped as normal control, streptozotocin-
induced diabetic control, normal treated with pelargonidin and
diabetic treated with pelargonidin.
Pelargonidin-treated rats received one time i.p injection of the
flavonoid (3 mg/kg bodyweight).
Biochemical parameters were assayed in blood samples of different
groups of rats.
Liver was used for histological examinations.
Pelargonidin treatment normalized elevated blood glucose levels and
improved serum insulin levels in diabetic rats.
Glucose tolerance test appeared normal after treatment. Decreased
serum levels of SOD and catalase, and increased levels of
malondialdehyde and fructosamine in diabetic rats were reverted to
their respective normal values after pelargonidin administration.
Extents of hemoglobin glycation, hemoglobin-mediated iron release,
iron-mediated free radical reactions and carbonyl formation in
hemoglobin were pronounced in diabetic rats, indicating association
between hemoglobin glycation and oxidative stress in diabetes.
Pelargonidin counteracts hemoglobin glycation, iron release from the
heme protein and iron-mediated oxidative damages, confirming glycated
hemoglobin-associated oxidative stress in diabetes.
Life sciences [Life Sci]
----------------------------------------------------------------------------=
----
Anthocyanin
=46rom Wikipedia, the free encyclopedia
Jump to: navigation, search
Anthocyanin gives these pansies their dark purple
pigmentation.Anthocyanins (from Greek: =E1=BC=80=CE=BD=CE=B8=CF=8C=CF=82 (an=
thos) =3D flower +
=CE=BA=CF=85=CE=B1=CE=BD=CF=8C=CF=82 (kyanos) =3D blue) are water-soluble va=
cuolar pigments that may
appear red, purple, or blue, according to pH. The pigment belongs to a
class of molecules called flavonoids, which are synthesized via the
phenylpropanoid pathway. Anthocyanins are synthesized by organisms in
the plant kingdom, and have been observed to occur in all tissues of
higher plants, including leaves, stems, roots, flowers, and fruits.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http :// tinyurl,com /2r2nkh
Man Is A Herbivore!
http :// tinyurl,com /a3cc3
DEAD PEOPLE WALKING
http :// tinyurl,com /zk9fk
