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Iron May Contribute To Aging
Iron May Contribute To Aging
Dysregulation of hepatic iron with aging: implications for heat stress-
induced oxidative liver injury.
Bloomer SA, Brown KE, Buettner GR, Kregel KC
Am J Physiol Regul Integr Comp Physiol 2008 Feb 13.
Environmental heat stress is associated with an age-related increase
in hepatic oxidative damage and an exaggerated state of oxidative
stress.
The purpose of this investigation was to evaluate the regulation of
hepatic iron after heat stress.
A secondary aim was to determine a potential role for iron in heat
stress-induced liver injury.
Hyperthermia-induced alterations in hepatic iron were evaluated in
young (6 mo) and old (24 mo) Fischer 344 rats by exposing them to a
two-heat stress protocol.
Livers were harvested at several time points after the second heating
and assayed for labile and nonheme iron.
In the control condition, there was no difference in labile iron
between age groups.
Both labile and storage iron were not altered by hyperthermia in young
rats, but both were increased immediately after heating in old rats.
To evaluate a role for iron in liver injury, hepatic iron content was
manipulated in young and old rats, then both groups were exposed to
heat stress.
Iron administration to young rats significantly increased hepatic iron
content and ferritin, but did not affect markers of lipid peroxidation
under control conditions or after heat stress.
In old rats, iron chelation with deferoxamine prevented the increase
in nonheme iron, labile iron, ferritin and lipid peroxidation after
heat stress.
These results suggest that iron may play a role in hepatic injury
after hyperthermia.
Thus, dysregulation of iron may contribute to the gradual decline in
cellular and physiological function that occurs with aging.
Key words: reactive oxygen species, deferoxamine, hyperthermia, EPR,
inflammation.
American journal of physiology. Regulatory, integrative and
comparative physiology [Am J Physiol Regul Integr Comp Physiol]
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Dysregulation of hepatic iron with aging: implications for heat stress-
induced oxidative liver injury.
Bloomer SA, Brown KE, Buettner GR, Kregel KC
Am J Physiol Regul Integr Comp Physiol 2008 Feb 13.
Environmental heat stress is associated with an age-related increase
in hepatic oxidative damage and an exaggerated state of oxidative
stress.
The purpose of this investigation was to evaluate the regulation of
hepatic iron after heat stress.
A secondary aim was to determine a potential role for iron in heat
stress-induced liver injury.
Hyperthermia-induced alterations in hepatic iron were evaluated in
young (6 mo) and old (24 mo) Fischer 344 rats by exposing them to a
two-heat stress protocol.
Livers were harvested at several time points after the second heating
and assayed for labile and nonheme iron.
In the control condition, there was no difference in labile iron
between age groups.
Both labile and storage iron were not altered by hyperthermia in young
rats, but both were increased immediately after heating in old rats.
To evaluate a role for iron in liver injury, hepatic iron content was
manipulated in young and old rats, then both groups were exposed to
heat stress.
Iron administration to young rats significantly increased hepatic iron
content and ferritin, but did not affect markers of lipid peroxidation
under control conditions or after heat stress.
In old rats, iron chelation with deferoxamine prevented the increase
in nonheme iron, labile iron, ferritin and lipid peroxidation after
heat stress.
These results suggest that iron may play a role in hepatic injury
after hyperthermia.
Thus, dysregulation of iron may contribute to the gradual decline in
cellular and physiological function that occurs with aging.
Key words: reactive oxygen species, deferoxamine, hyperthermia, EPR,
inflammation.
American journal of physiology. Regulatory, integrative and
comparative physiology [Am J Physiol Regul Integr Comp Physiol]
----------------------------------------------------------------------------=
----------------------------------------------------------------------------=
--------
Who loves ya.
Tom
Jesus Was A Vegetarian!
* tinyurl . com /2r2nkh
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
