Supplements for Neuropathy

Supplements for Neuropathy

What supplements provide relief from polyneuropathy? Would the
following be the most important? Already doing paleo-type diet,
moderate exercise and multi-vitamins.

Benfotiamine
Vitamin B6 (P-5-P)
R-Lipoic Acid
NAC
Acetyl-L-Carnitine

Re: Supplements for Neuropathy

On Thu, 15 May 2008 09:46:29 -0700 (PDT), jay <jaym1212@hotmail . com >
wrote:

>What supplements provide relief from polyneuropathy? Would the
>following be the most important? Already doing paleo-type diet,
>moderate exercise and multi-vitamins.
>
>Benfotiamine
>Vitamin B6 (P-5-P)
>R-Lipoic Acid
>NAC
>Acetyl-L-Carnitine


I can get you an incredible deal on the Statue of Liberty, 25% off the
cheapest price you can find from anyone else.

Re: Supplements for Neuropathy


"jay" <jaym1212@hotmail . com > wrote in message
news:739091c9-61a5-4257-844a-cbc2e72bd0e6@r66g2000hsg.googlegroups . com ...
> What supplements provide relief from polyneuropathy? Would the
> following be the most important? Already doing paleo-type diet,
> moderate exercise and multi-vitamins.
>
> Benfotiamine
> Vitamin B6 (P-5-P)
> R-Lipoic Acid
> NAC
> Acetyl-L-Carnitine

I don't know what NAC is. But Evening Primrose Oil is not on your list.
That's the biggie. I think...

Re: Supplements for Neuropathy

> ... Evening Primrose Oil is not on your list.
> That's the biggie. I think...

Thanks.

> I don't know what NAC is.  

Inhibition of development of peripheral neuropathy in streptozotocin-
induced diabetic rats with N-acetylcysteine.

N-acetylcysteine (NAC) is a precursor of glutathione (GSH) synthesis,
a free radical scavenger and an inhibitor of tumour necrosis factor
alpha (TNF). Because these functions might be beneficial in diabetic
complications, in this study we examined whether NAC inhibits
peripheral neuropathy. Motor nerve conduction velocity (MNCV) was
significantly decreased in streptozotocin-induced-diabetic Wistar rats
compared to control rats. Oral administration of NAC reduced the
decline of MNCV in diabetic rats. Structural analysis of the sural
nerve disclosed significant reduction of fibres undergoing myelin
wrinkling and inhibition of myelinated fibre atrophy in NAC-treated
diabetic rats. NAC treatment had no effect on blood glucose levels or
on the nerve glucose, sorbitol and cAMP contents, whereas it corrected
the decreased GSH levels in erythrocytes, the increased lipid peroxide
levels in plasma and the increased lipopolysaccharide-induced TNF
activity in sera of diabetic rats. Thus, NAC inhibited the development
of functional and structural abnormalities of the peripheral nerve in
streptozotocin-induced diabetic rats. PMID: 8721770

Re: Supplements for Neuropathy

> ... Evening Primrose Oil is not on your list.

Below abstract says, in general LA more effective, but EPO/GLA better
for ileum related neuropathy. Is there any commonly available food
with GLA?

The effectiveness of treatments of diabetic autonomic neuropathy is
not the same in autonomic nerves supplying different organs.

The aim of the study was to investigate antioxidant (alpha-lipoic acid
[LA]) and gamma-linolenic acid treatments in the prevention of changes
in autonomic nerves induced in streptozotocin-diabetic rats. Autonomic
nerves supplying the heart, penis, and gut were examined using
immunohistochemical and biochemical techniques. LA and gamma-linolenic
acid (present in evening primrose oil [EPO]) were administered as
dietary supplements ( approximately 80 and 200 mg. kg(-1). day(-1),
respectively). LA treatment prevented the diabetes-induced decrease of
norepinephrine (NA) in the heart and of type I nitric oxide synthase
(NOS-I) expression in erectile tissue of the penis but failed to
prevent diabetes-induced changes in NA-, vasoactive intestinal
polypeptide-, or calcitonin gene-related peptide-containing nerves
supplying the ileum. LA partially prevented and EPO totally prevented
the increase in NOS-I activity induced by diabetes in the ileum. EPO
treatment failed to prevent any other diabetes-induced changes in the
heart, penis, or ileum. These results demonstrate that, whereas LA
treatment is more effective than EPO in preventing diabetes-induced
changes in autonomic nerves, the effectiveness of LA treatment varies
with the target organ studied. Diabetes-induced changes in nerves
supplying the ileum are more resistant to treatment than those of the
heart and penis.
PMID: 12502507

Re: Supplements for Neuropathy

jay wrote:
> What supplements provide relief from polyneuropathy? Would the
> following be the most important? Already doing paleo-type diet,
> moderate exercise and multi-vitamins.
>
> Benfotiamine
> Vitamin B6 (P-5-P)
> R-Lipoic Acid
> NAC
> Acetyl-L-Carnitine

take a look at this article......... it includes the studies done as well
* w w w .diabetic-talk.org/dpn.htm

--
kate
type 1 since 1987
w w w .diabetic-talk.org
* w w w .diabetes-support.org.uk/newly%20diagnosed.html

Re: Supplements for Neuropathy

> take a look at ..... w w w .diabetic-talk.org/dpn.htm

Thanks. They recommends a cocktail of slow-released Lipoic Acid, EPO
and Vitamin C. Is the reason why EPO helps neuropathy well
established? Is the below related?

Choice of oils for essential fat supplements can enhance production of
abnormal metabolites in fat oxidation disorders.

Patients with mitochondrial long-chain fat oxidation deficiencies are
usually treated with diets containing reduced fat and increased
carbohydrate, at times via gastrostomy feeding. To ensure adequate
intake of essential fatty acids, supplements are provided to their
diets using commercially available oils. These oils contain large
quantities of non-essential fats that are preferentially oxidized and
produce disease-specific metabolites (acyl-CoA intermediates) due to
the genetic defect. This study describes the concentrations of these
intermediates as reflected by acylcarnitines as well as the %
contribution from each of four fatty acids: palmitate, oleate,
linoleate, and alpha-linolenate when incubated with fibroblasts from
patients with VLCAD, LCHAD, and trifunctional protein (TFP)
deficiencies. Palmitate and oleate produce the majority of disease-
specific acylcarnitines with these defective cell lines (79-94%)
whereas linoleate and linolenate produced less (6-21%). On average,
the amount of acylcarnitines decreased with increasing unsaturation
(C18:1>C18:2>C18:3:34%>11%>3%, respectively. This relationship may
reflect the "gatekeeper" role of carnitine palmitoyltransferase I (CPT
I). A diet comparison between Canola and a combination of Flax/Walnut
oils revealed that the latter, containing the least amount of non-
essential fats, reduced blood acylcarnitine levels by 33-36%. The
etiology of the severe peripheral neuropathy of TFP deficiency may
result from the unique metabolite, 3-keto-acyl-CoA, after conversion
to a methylketone via spontaneous decarboxylation. Essential fatty
acid supplementation with oils should consider these findings to
decrease production of disease-specific acyl-CoA intermediates. PMID:
17825594

Re: Supplements for Neuropathy

jay wrote:
>> take a look at ..... w w w .diabetic-talk.org/dpn.htm
>
> Thanks. They recommends a cocktail of slow-released Lipoic Acid, EPO
> and Vitamin C. Is the reason why EPO helps neuropathy well
> established? Is the below related?

i don't know the details, i didn't write the article, nor do the
research for it

i DO KNOW 6 or 7 diabetics who no longer have the tingling/burning/socks
under the toes feelings that they used to have

good bg control is imperative as well....

--
kate
type 1 since 1987
w w w .diabetic-talk.org
* w w w .diabetes-support.org.uk/newly%20diagnosed.html

Re: Supplements for Neuropathy

On Fri, 16 May 2008 12:09:15 -0600, Tiger_Lily <me@privacy . net > wrote:

>jay wrote:
>>> take a look at ..... w w w .diabetic-talk.org/dpn.htm
>>
>> Thanks. They recommends a cocktail of slow-released Lipoic Acid, EPO
>> and Vitamin C. Is the reason why EPO helps neuropathy well
>> established? Is the below related?
>
>i don't know the details, i didn't write the article, nor do the
>research for it
>
>i DO KNOW 6 or 7 diabetics who no longer have the tingling/burning/socks
>under the toes feelings that they used to have
>
>good bg control is imperative as well....

Agreed, also beware that the ALA may knock down your BG some, so it
can have a double whammy in improving the neuropathy per se and also
improving the BG. I use the non-time release kind and have found it
not only knocks out my overenthusiastic liver but leaves me prone to
getting down to near-hypo levels.

Re: Supplements for Neuropathy

Tiger Lily wrote:
> jay wrote:
>>> take a look at ..... w w w .diabetic-talk.org/dpn.htm
>> Thanks. They recommends a cocktail of slow-released Lipoic Acid, EPO
>> and Vitamin C. Is the reason why EPO helps neuropathy well
>> established? Is the below related?
>
> i don't know the details, i didn't write the article, nor do the
> research for it
>
> i DO KNOW 6 or 7 diabetics who no longer have the tingling/burning/socks
> under the toes feelings that they used to have
>
> good bg control is imperative as well....
>

That burning-foot problem might be related to circulatory, not
neurological, trouble. I had that symptom when my cholesterol was high.

Adele Davis recommended pantothenic acid (vitamin B5) for burning
feet, which didn't help me. But pantethine, which is closely related to
it, is among the three B vitamins, including niacin (vitamin B3) and
pyridoxine (vitamin B6), which definitely do lower LDL cholesterol. (I
don't know much about pantethine, but pantothenic acid works the same
way, costs much less, and is almost as effective.)

And I ate two to six cups of cooked oat bran every day, which also
has been proven to work.

The peripheral neuropathy I cleared up by taking thiamine (vitamin
B1) was different. It showed up as a small area of numbness on the
medial aspect of my right big toe -- and it went away fast, probably
because I reacted quickly.

In any case, losing one third of my weight by fasting seems to have
solved both problems permanently for me -- and not only did it cost
nothing, but it actually saved me my food budget for six weeks!


--
Marshall Price of Miami
Known to Yahoo as d021317c

Re: Supplements for Neuropathy


> And I ate two to six cups of cooked oat bran every day, which also
> has been proven to work.

Make sure you rule out Celiac disease first. It's associated with
neuropathies.

Re: Supplements for Neuropathy

> > And I ate two to six cups of cooked oat bran every day,
> > which also has been proven to work.
>
> Make sure you rule out Celiac disease first.  It's associated with
> neuropathies.

I think unadulterated oats are now considered safe; however, oats can
be contaminated by equipment/facilities that also process wheat,
barley or rye.

In the past, after eating Cinnamon Toast Crunch cereal (wheat, sugar,
rice flour, canola, fructose, maltodextrin, dextrose) for two weeks,
any meal with usual amount of hot chilies would cause both of my hands/
wrist to feel as if capsaicin was applied there direclty. Other corn/
oat based cereals didn't have this effect.

Re: Supplements for Neuropathy

On Tue, 3 Jun 2008 14:00:38 -0700 (PDT), jay <jaym1212@hotmail . com >
wrote:

>> > And I ate two to six cups of cooked oat bran every day,
>> > which also has been proven to work.
>>
>> Make sure you rule out Celiac disease first.  It's associated with
>> neuropathies.
>
>I think unadulterated oats are now considered safe; however, oats can
>be contaminated by equipment/facilities that also process wheat,
>barley or rye.
>
>In the past, after eating Cinnamon Toast Crunch cereal (wheat, sugar,
>rice flour, canola, fructose, maltodextrin, dextrose) for two weeks,
>any meal with usual amount of hot chilies would cause both of my hands/
>wrist to feel as if capsaicin was applied there direclty. Other corn/
>oat based cereals didn't have this effect.

Did it also affect your feet?

Was it symmetrical?

Did you check your blood glucose?

I can't speak for anyone else but that many fast carbs would spike my
BG and cause the onset of peripheral neuropathy

The chillies might just amplify the pain

Re: Supplements for Neuropathy

>> In the past, after eating Cinnamon Toast Crunch cereal fo two weeks,
>> any meal with usual amount of hot chilies would cause both of my hands/
>> wrist to feel as if capsaicin was applied there direclty.
>
> Did it also affect your feet?

No, and I haven't had any numbness/tingling in my feet. But they do
get sore from walking, possibly more so when consuming beef and
chicken.

> Was it symmetrical?

Yes, the icy/hot feeling in hands and wrists was symmetrical.

> Did you check your blood glucose?

No, but based on past measurements, it probably went in to the mid
100's.

> I can't speak for anyone else but that many fast carbs would spike my
> BG and cause the onset of peripheral neuropathy

Me too, and that was one of the reasons for shifting more to meats.

> The chillies might just amplify the pain

Actually, the icy/hot feeling generated by chillies feels good in a
weird way and drowns out the more aggravating pain/numbness.

Re: Supplements for Neuropathy

jay wrote:
> What supplements provide relief from polyneuropathy? Would the
> following be the most important? Already doing paleo-type diet,
> moderate exercise and multi-vitamins.
>
> Benfotiamine
> Vitamin B6 (P-5-P)
> R-Lipoic Acid
> NAC
> Acetyl-L-Carnitine

In our collective clinical experience, no supplement(s) can overcome
the deleterious effect that PIACs from VAT (black fat) has on the
fragile efferent fibers of sensory neurons thereby causing the
peripheral neuropathy.

Be hungry... be healthy... be hungrier... be healthier...

Prayerfully in the awesome name of LORD Jesus Christ,

Andrew <><
--
* groups.google . com /group/sci.med.cardiology/msg/cd9918679e6b3d6f?