Management Of Chronic Fatigue

Management Of Chronic Fatigue

http :// www .majidali,com /Hypothesis.htm

Majid Ali, M.D.

ABSTRACT:
A hypothesis is proposed that chronic fatigue is a state of
accelerated oxidative molecular injury.
Evidence supporting the hypothesis includes the following:
1. Spontaneity of oxidation in nature is the basic cause of the aging
process for organisms capable of aerobic respiration.
Redox dysregulations represent the initial events that lead to
clinical disease processes.
2. Incidence of chronic fatigue is increasing, as is the oxidant
stress in the Earth's atmosphere.
3. Evidence for oxidative cell membrane injury in chronic fatigue is
furnished by changes in intracellular and extracellular ions.
4. Immunologic abnormalities that occur in chronic fatigue
are consistent with initial oxidative injury.
5. Commonality of association of antigens of HLA-DR3 region with
chronic fatigue syndrome and with other immune disorders such as
rheumatoid arthritis, pemphigus vulgaris, systemic lupus
erythematosus, and IgA and gold nephropathies.
6. Direct morphologic evidence of increased oxidative stress on the
cell membrane is shown by the fact that we have found membrane
deformities in up to 80% of erythrocytes in blood from chronic fatigue
syndrome patients.
These deformities are quickly reversed by administering ascorbic acid
intravenously.
7. Changes in electromyopotentials observed in chronic fatigue
patients are consistent with intracellular ionic and membrane
changes.
8. Clinical entities commonly associated with chronic
fatigue are known to increase oxidative molecular stress.
9. Clinical evidence obtained with relief of fatigue and related
muscle symptoms with the use of oral and intravenous antioxidant
nutrient therapy.
From a clinical standpoint, this model for the molecular basis of
chronic fatigue is useful for making therapeutic decisions for
successful management of chronic fatigue without drug regimens.
---------------

"Restriction of iron may have positive effects on health in general
and aging in particular"

Galaris D, Mantzaris M, Amorgianiotis C
Oxidative stress and aging: the potential role of iron. [Journal
Article]
Hormones (Athens) 2008 Apr-Jun; 7(2):114-22.


According to the free radical theory of aging proposed by Denham
Harman more than 50 years ago, oxidatively modified cellular
components accumulate continuously in the cells during the organism's
lifespan leading to progressive decline of cellular functions. Since
then, it has been shown that proteins, lipids, nucleic acids and
other
cell components undergo reversible and/or irreversible oxidative
modifications during aging. Moreover, oxidized cell components can
undergo further oxidative modifications leading to formation of
products that cell degradation systems are incapable of removing.
Accumulation of such non-degradable aggregates further inhibits the
functionality of degradation systems, thus aggravating the effects
and
leading to a vicious cycle. In this presentation, we propose that the
availability of intracellular iron in its redox active form (labile
iron) represents the main catalyst that mediates extensive oxidative
modifications of cellular components and ultimately leads to their
accumulation and consequent cellular dysfunction. It is tempting to
speculate that regulated restriction of labile iron may have positive
effects on health in general and aging in particular.
Hormones (Athens, Greece) [Hormones (Athens)]
---------------------------------------------------------------------------­-----

Who loves ya.
Tom


Jesus Was A Vegetarian!
http :// tinyurl,com /2r2nkh


Man Is A Herbivore!
http :// tinyurl,com /a3cc3


DEAD PEOPLE WALKING
http :// tinyurl,com /zk9fk

Re: Vitamin C for Management Of Chronic Fatigue

50mg/kg Vitamin C for Chronic Fatigue.
See, I'm not even telling you about the Kreb Cycle, and its need for
Vitamin C for energy production (it is after all called the citric
acid cycle)
Article at http :// www .krysalis,net /chronicfatigue.htm proposes why MSM
may be of value for some CF and FMS'ers, too.

On May 18, 12:00 am, ironjustice <teamtan...@hotmail,com > wrote:

> 6. Direct morphologic evidence of increased oxidative stress on the
> cell membrane is shown by the fact that we have found membrane
> deformities in up to 80% of erythrocytes in blood from chronic fatigue
> syndrome patients.
> These deformities are quickly reversed by administering ascorbic acid
> intravenously.

Re: Management Of Chronic Fatigue

On May 17, 10:34 pm, Michael B <baugh...@bellsouth,net > wrote:
50mg/kg Vitamin C for Chronic Fatigue. <<

Of course .. michael .. tells a person with HIGH ..chances of BEING
iron overloaded / aplastic anemia .. to .."take vitamin C"..

"Vitamin C, like any drug, can have serious side effects. For
vitamin
C, these effects appear more frequently in people who have iron
overload (e.g., hemochromatosis or multiple transfusions) or who use
unneeded iron supplements."

Greg Froehlich, MD
White River Junction, VT

------------------

On May 17, 10:34 pm, Michael B <baugh...@bellsouth,net > wrote:
See, I'm not even telling you about the Kreb Cycle, <<

Seeing what you know nothing about Vitamin C .. I'm glad you didn't
tell us what you .. think .. you know .. about the Krebs .. cycle.

Heh ..heh ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http :// tinyurl,com /2r2nkh


Man Is A Herbivore!
http :// tinyurl,com /a3cc3


DEAD PEOPLE WALKING
http :// tinyurl,com /zk9fk

for energy production (it is after all called the citric
acid cycle)
> Article at http :// www .krysalis,net /chronicfatigue.htmproposes why MSM
> may be of value for some CF and FMS'ers, too.
>
> On May 18, 12:00 am, ironjustice <teamtan...@hotmail,com > wrote:
>
>
>
> > 6. Direct morphologic evidence of increased oxidative stress on the
> > cell membrane is shown by the fact that we have found membrane
> > deformities in up to 80% of erythrocytes in blood from chronic fatigue
> > syndrome patients.
> > These deformities are quickly reversed by administering ascorbic acid
> > intravenously.- Hide quoted text -
>
> - Show quoted text -

Reversal of most diseases by iron overload correction

Yep, vitamin C helps with the absorption of iron.
You look at the world and see every person that's sick as a
likely candidate for a diagnosis of iron overload. So you see it as
your mission to get everyone to avoid iron excess. Well, let's let
all who have been the recipient of that message tell you how
they've started giving blood, become a vegetarian, started chelation
therapy, all that.

Everybody that wants to express their appreciation to John for
pointing out the way to wellness please respond to this invitation.
Let him know how thankful you are that he has pointed all this out
to you.

Go ahead, tell him how you feel about his giving you his message.


On May 18, 12:21 pm, "ironjust...@aol,com " <ironjust...@aol,com >
wrote:
> On May 17, 10:34 pm, Michael B <baugh...@bellsouth,net > wrote:
> 50mg/kg Vitamin C for Chronic Fatigue. <<
>
> Of course .. michael .. tells a person with HIGH ..chances of BEING
> iron overloaded / aplastic anemia .. to .."take vitamin C"..
>
> "Vitamin C, like any drug, can have serious side effects. For
> vitamin
> C, these effects appear more frequently in people who have iron
> overload (e.g., hemochromatosis or multiple transfusions) or who use
> unneeded iron supplements."
>
> Greg Froehlich, MD
> White River Junction, VT
>
> ------------------
>
> On May 17, 10:34 pm, Michael B <baugh...@bellsouth,net > wrote:
> See, I'm not even telling you about the Kreb Cycle, <<
>
> Seeing what you know nothing about Vitamin C .. I'm glad you didn't
> tell us what you .. think .. you know .. about the Krebs .. cycle.
>
> Heh ..heh ..
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! http :// tinyurl,com /2r2nkh
>
> Man Is A Herbivore! http :// tinyurl,com /a3cc3
>
> DEAD PEOPLE WALKING http :// tinyurl,com /zk9fk
>
> for energy production (it is after all called the citric
> acid cycle)
>
> > Article at http :// www .krysalis,net /chronicfatigue.htmproposeswhy MSM
> > may be of value for some CF and FMS'ers, too.
>
> > On May 18, 12:00 am, ironjustice <teamtan...@hotmail,com > wrote:
>
> > > 6. Direct morphologic evidence of increased oxidative stress on the
> > > cell membrane is shown by the fact that we have found membrane
> > > deformities in up to 80% of erythrocytes in blood from chronic fatigue
> > > syndrome patients.
> > > These deformities are quickly reversed by administering ascorbic acid
> > > intravenously.- Hide quoted text -
>
> > - Show quoted text -

Management Of Chronic Fatigue

http :// www .majidali,com /Hypothesis.htm

Majid Ali, M.D.


ABSTRACT:
A hypothesis is proposed that chronic fatigue is a state of
accelerated oxidative molecular injury.
Evidence supporting the hypothesis includes the following:
1. Spontaneity of oxidation in nature is the basic cause of the aging
process for organisms capable of aerobic respiration.
Redox dysregulations represent the initial events that lead to
clinical disease processes.
2. Incidence of chronic fatigue is increasing, as is the oxidant
stress in the Earth's atmosphere.
3. Evidence for oxidative cell membrane injury in chronic fatigue is
furnished by changes in intracellular and extracellular ions.
4. Immunologic abnormalities that occur in chronic fatigue
are consistent with initial oxidative injury.
5. Commonality of association of antigens of HLA-DR3 region with
chronic fatigue syndrome and with other immune disorders such as
rheumatoid arthritis, pemphigus vulgaris, systemic lupus
erythematosus, and IgA and gold nephropathies.
6. Direct morphologic evidence of increased oxidative stress on the
cell membrane is shown by the fact that we have found membrane
deformities in up to 80% of erythrocytes in blood from chronic
fatigue
syndrome patients.
These deformities are quickly reversed by administering ascorbic acid
intravenously.
7. Changes in electromyopotentials observed in chronic fatigue
patients are consistent with intracellular ionic and membrane
changes.
8. Clinical entities commonly associated with chronic
fatigue are known to increase oxidative molecular stress.
9. Clinical evidence obtained with relief of fatigue and related
muscle symptoms with the use of oral and intravenous antioxidant
nutrient therapy.
From a clinical standpoint, this model for the molecular basis of
chronic fatigue is useful for making therapeutic decisions for
successful management of chronic fatigue without drug regimens.
---------------


"Restriction of iron may have positive effects on health in general
and aging in particular"


Galaris D, Mantzaris M, Amorgianiotis C
Oxidative stress and aging: the potential role of iron. [Journal
Article]
Hormones (Athens) 2008 Apr-Jun; 7(2):114-22.


According to the free radical theory of aging proposed by Denham
Harman more than 50 years ago, oxidatively modified cellular
components accumulate continuously in the cells during the organism's
lifespan leading to progressive decline of cellular functions. Since
then, it has been shown that proteins, lipids, nucleic acids and
other
cell components undergo reversible and/or irreversible oxidative
modifications during aging. Moreover, oxidized cell components can
undergo further oxidative modifications leading to formation of
products that cell degradation systems are incapable of removing.
Accumulation of such non-degradable aggregates further inhibits the
functionality of degradation systems, thus aggravating the effects
and
leading to a vicious cycle. In this presentation, we propose that the
availability of intracellular iron in its redox active form (labile
iron) represents the main catalyst that mediates extensive oxidative
modifications of cellular components and ultimately leads to their
accumulation and consequent cellular dysfunction. It is tempting to
speculate that regulated restriction of labile iron may have positive
effects on health in general and aging in particular.
Hormones (Athens, Greece) [Hormones (Athens)]
---------------------------------------------------------------------------­­-----


Who loves ya.
Tom


Jesus Was A Vegetarian!
http :// tinyurl,com /2r2nkh


Man Is A Herbivore!
http :// tinyurl,com /a3cc3

Vitamin C for Management Of Chronic Fatigue

Isn't this the same stuff posted at the beginning of the thread?
Why, by golly, it sure is. And the note in item #6 how the erythrocyte
deformities were quickly reversed with intravenous administration of
Vitamin C. It's still there, telling how to deal with the oxidative
stress
postulated by the author you've noted.
Just wanted to help you with your crusade.

On May 18, 7:20 pm, "ironjust...@aol,com " <ironjust...@aol,com > wrote:
> http :// www .majidali,com /Hypothesis.htm
>
> Majid Ali, M.D.
>
> ABSTRACT:
> A hypothesis is proposed that chronic fatigue is a state of
> accelerated oxidative molecular injury.
> Evidence supporting the hypothesis includes the following:
> 1. Spontaneity of oxidation in nature is the basic cause of the aging
> process for organisms capable of aerobic respiration.
> Redox dysregulations represent the initial events that lead to
> clinical disease processes.
> 2. Incidence of chronic fatigue is increasing, as is the oxidant
> stress in the Earth's atmosphere.
> 3. Evidence for oxidative cell membrane injury in chronic fatigue is
> furnished by changes in intracellular and extracellular ions.
> 4. Immunologic abnormalities that occur in chronic fatigue
> are consistent with initial oxidative injury.
> 5. Commonality of association of antigens of HLA-DR3 region with
> chronic fatigue syndrome and with other immune disorders such as
> rheumatoid arthritis, pemphigus vulgaris, systemic lupus
> erythematosus, and IgA and gold nephropathies.
> 6. Direct morphologic evidence of increased oxidative stress on the
> cell membrane is shown by the fact that we have found membrane
> deformities in up to 80% of erythrocytes in blood from chronic
> fatigue
> syndrome patients.
> These deformities are quickly reversed by administering ascorbic acid
> intravenously.
> 7. Changes in electromyopotentials observed in chronic fatigue
> patients are consistent with intracellular ionic and membrane
> changes.
> 8. Clinical entities commonly associated with chronic
> fatigue are known to increase oxidative molecular stress.
> 9. Clinical evidence obtained with relief of fatigue and related
> muscle symptoms with the use of oral and intravenous antioxidant
> nutrient therapy.
> From a clinical standpoint, this model for the molecular basis of
> chronic fatigue is useful for making therapeutic decisions for
> successful management of chronic fatigue without drug regimens.
> ---------------
>
> "Restriction of iron may have positive effects on health in general
> and aging in particular"
>
> Galaris D, Mantzaris M, Amorgianiotis C
> Oxidative stress and aging: the potential role of iron. [Journal
> Article]
> Hormones (Athens) 2008 Apr-Jun; 7(2):114-22.
>
> According to the free radical theory of aging proposed by Denham
> Harman more than 50 years ago, oxidatively modified cellular
> components accumulate continuously in the cells during the organism's
> lifespan leading to progressive decline of cellular functions. Since
> then, it has been shown that proteins, lipids, nucleic acids and
> other
> cell components undergo reversible and/or irreversible oxidative
> modifications during aging. Moreover, oxidized cell components can
> undergo further oxidative modifications leading to formation of
> products that cell degradation systems are incapable of removing.
> Accumulation of such non-degradable aggregates further inhibits the
> functionality of degradation systems, thus aggravating the effects
> and
> leading to a vicious cycle. In this presentation, we propose that the
> availability of intracellular iron in its redox active form (labile
> iron) represents the main catalyst that mediates extensive oxidative
> modifications of cellular components and ultimately leads to their
> accumulation and consequent cellular dysfunction. It is tempting to
> speculate that regulated restriction of labile iron may have positive
> effects on health in general and aging in particular.
> Hormones (Athens, Greece) [Hormones (Athens)]
> ---------------------------------------------------------------------------­­-----
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! http :// tinyurl,com /2r2nkh
>
> Man Is A Herbivore! http :// tinyurl,com /a3cc3

Re: Vitamin C for Management Of Chronic Fatigue

On May 18, 4:32 pm, Michael B <baugh...@bellsouth,net > wrote:
Isn't this the same stuff posted at the beginning of the thread? <<

You have a reason to BE .. on this thread .. do ya .. ?

You tell people with aplastic anemia to take .. iron ..

I place one of many studies which show this NOT to be a good thing in
people with aplastic anemia / transfusions.

Sooo .. your medical advice is wanting.

Try not to give medical advice.

You may go to jail or lose your posting privileges ..

YOU .. medical advice.. ?

Heh .. heh ..

On May 18, 4:32 pm, Michael B <baugh...@bellsouth,net > wrote: Why, by
golly, it sure is. And the note in item #6 how the erythrocyte
deformities were quickly reversed with intravenous administration of
Vitamin C. It's still there, telling how to deal with the oxidative
stress postulated by the author you've noted. Just wanted to help you
with your crusade. <<

Help .. ?

Who you trying to fool .. ?

Postulated means .. guessing .. he wasn't guess .. he say they were
"quickly reversed".
You consider that to BE .. postulation .. do ya .. ?

Who cares whether he cures them with vitamin C or not.
The postulation IS .. oxidative stress leading to chronic fatigue.
You gonna inject some vitamin C are ya .. ?
How you going to manage to DO .. that .. ?


Who loves ya.
Tom


Jesus Was A Vegetarian!
http :// tinyurl,com /2r2nkh


Man Is A Herbivore!
http :// tinyurl,com /a3cc3


DEAD PEOPLE WALKING
http :// tinyurl,com /zk9fk

>
> On May 18, 7:20 pm, "ironjust...@aol,com " <ironjust...@aol,com > wrote:
>
>
>
> > http :// www .majidali,com /Hypothesis.htm
>
> > Majid Ali, M.D.
>
> > ABSTRACT:
> > A hypothesis is proposed that chronic fatigue is a state of
> > accelerated oxidative molecular injury.
> > Evidence supporting the hypothesis includes the following:
> > 1. Spontaneity of oxidation in nature is the basic cause of the aging
> > process for organisms capable of aerobic respiration.
> > Redox dysregulations represent the initial events that lead to
> > clinical disease processes.
> > 2. Incidence of chronic fatigue is increasing, as is the oxidant
> > stress in the Earth's atmosphere.
> > 3. Evidence for oxidative cell membrane injury in chronic fatigue is
> > furnished by changes in intracellular and extracellular ions.
> > 4. Immunologic abnormalities that occur in chronic fatigue
> > are consistent with initial oxidative injury.
> > 5. Commonality of association of antigens of HLA-DR3 region with
> > chronic fatigue syndrome and with other immune disorders such as
> > rheumatoid arthritis, pemphigus vulgaris, systemic lupus
> > erythematosus, and IgA and gold nephropathies.
> > 6. Direct morphologic evidence of increased oxidative stress on the
> > cell membrane is shown by the fact that we have found membrane
> > deformities in up to 80% of erythrocytes in blood from chronic
> > fatigue
> > syndrome patients.
> > These deformities are quickly reversed by administering ascorbic acid
> > intravenously.
> > 7. Changes in electromyopotentials observed in chronic fatigue
> > patients are consistent with intracellular ionic and membrane
> > changes.
> > 8. Clinical entities commonly associated with chronic
> > fatigue are known to increase oxidative molecular stress.
> > 9. Clinical evidence obtained with relief of fatigue and related
> > muscle symptoms with the use of oral and intravenous antioxidant
> > nutrient therapy.
> > From a clinical standpoint, this model for the molecular basis of
> > chronic fatigue is useful for making therapeutic decisions for
> > successful management of chronic fatigue without drug regimens.
> > ---------------
>
> > "Restriction of iron may have positive effects on health in general
> > and aging in particular"
>
> > Galaris D, Mantzaris M, Amorgianiotis C
> > Oxidative stress and aging: the potential role of iron. [Journal
> > Article]
> > Hormones (Athens) 2008 Apr-Jun; 7(2):114-22.
>
> > According to the free radical theory of aging proposed by Denham
> > Harman more than 50 years ago, oxidatively modified cellular
> > components accumulate continuously in the cells during the organism's
> > lifespan leading to progressive decline of cellular functions. Since
> > then, it has been shown that proteins, lipids, nucleic acids and
> > other
> > cell components undergo reversible and/or irreversible oxidative
> > modifications during aging. Moreover, oxidized cell components can
> > undergo further oxidative modifications leading to formation of
> > products that cell degradation systems are incapable of removing.
> > Accumulation of such non-degradable aggregates further inhibits the
> > functionality of degradation systems, thus aggravating the effects
> > and
> > leading to a vicious cycle. In this presentation, we propose that the
> > availability of intracellular iron in its redox active form (labile
> > iron) represents the main catalyst that mediates extensive oxidative
> > modifications of cellular components and ultimately leads to their
> > accumulation and consequent cellular dysfunction. It is tempting to
> > speculate that regulated restriction of labile iron may have positive
> > effects on health in general and aging in particular.
> > Hormones (Athens, Greece) [Hormones (Athens)]
> > ---------------------------------------------------------------------------­­­-----
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian! http :// tinyurl,com /2r2nkh
>
> > Man Is A Herbivore! http :// tinyurl,com /a3cc3- Hide quoted text -
>
> - Show quoted text -

Re: Vitamin C for Management Of Chronic Fatigue


Oh, John, I just SO ENJOY working with you. Gives me that warm
fuzzy feeling. Know what I mean?
Naah, I don't tell the ones with aplastic anemia to take iron, I
remind
them that YOUR cited commentary told about reversal of erythrocyte
damage from the oxidative stress with use of intravenous Vitamin C.

You DO read these things before you post them, don't you? I'd hate to
think a Health Research Analyst such as yourself would just post
something without noting such an obvious suggestion towards dealing
with the damage of oxidative stress. Of course, it isn't like it's a
new
revelation, Vitamin C is used to reduce radiation injury, too.

But, hey, now that I'm your partner on this, what do you mean by
"> Who cares whether he cures them with vitamin C or not.
> The postulation IS .. oxidative stress leading to chronic fatigue."

You're the one telling people how to manage Chronic Fatigue. And
you have done it by reminding them that IV Vitamin C corrected the
tissue deformities.

GOOD FOR YOU!!. Isn't he great? He gave a better alternative than
becoming a grass-eater. Take the vitamin C to reduce the effect of
oxidative stress.

John, what a stroke of genius on your part. Or was it just a stroke?

On May 18, 7:51 pm, "ironjust...@aol,com " <ironjust...@aol,com > wrote:
> On May 18, 4:32 pm, Michael B <baugh...@bellsouth,net > wrote:
> Isn't this the same stuff posted at the beginning of the thread? <<
>
> You have a reason to BE .. on this thread .. do ya .. ?
>
> You tell people with aplastic anemia to take .. iron ..
>
> I place one of many studies which show this NOT to be a good thing in
> people with aplastic anemia / transfusions.
>
> Sooo .. your medical advice is wanting.
>
> Try not to give medical advice.
>
> You may go to jail or lose your posting privileges ..
>
> YOU .. medical advice.. ?
>
> Heh .. heh ..
>
> On May 18, 4:32 pm, Michael B <baugh...@bellsouth,net > wrote: Why, by
> golly, it sure is. And the note in item #6 how the erythrocyte
> deformities were quickly reversed with intravenous administration of
> Vitamin C. It's still there, telling how to deal with the oxidative
> stress postulated by the author you've noted. Just wanted to help you
> with your crusade. <<
>
> Help .. ?
>
> Who you trying to fool .. ?
>
> Postulated means .. guessing .. he wasn't guess .. he say they were
> "quickly reversed".
> You consider that to BE .. postulation .. do ya .. ?
>
> Who cares whether he cures them with vitamin C or not.
> The postulation IS .. oxidative stress leading to chronic fatigue.
> You gonna inject some vitamin C are ya .. ?
> How you going to manage to DO .. that .. ?
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! http :// tinyurl,com /2r2nkh
>
> Man Is A Herbivore! http :// tinyurl,com /a3cc3
>
> DEAD PEOPLE WALKING http :// tinyurl,com /zk9fk
>
>
>
> > On May 18, 7:20 pm, "ironjust...@aol,com " <ironjust...@aol,com > wrote:
>
> > > http :// www .majidali,com /Hypothesis.htm
>
> > > Majid Ali, M.D.
>
> > > ABSTRACT:
> > > A hypothesis is proposed that chronic fatigue is a state of
> > > accelerated oxidative molecular injury.
> > > Evidence supporting the hypothesis includes the following:
> > > 1. Spontaneity of oxidation in nature is the basic cause of the aging
> > > process for organisms capable of aerobic respiration.
> > > Redox dysregulations represent the initial events that lead to
> > > clinical disease processes.
> > > 2. Incidence of chronic fatigue is increasing, as is the oxidant
> > > stress in the Earth's atmosphere.
> > > 3. Evidence for oxidative cell membrane injury in chronic fatigue is
> > > furnished by changes in intracellular and extracellular ions.
> > > 4. Immunologic abnormalities that occur in chronic fatigue
> > > are consistent with initial oxidative injury.
> > > 5. Commonality of association of antigens of HLA-DR3 region with
> > > chronic fatigue syndrome and with other immune disorders such as
> > > rheumatoid arthritis, pemphigus vulgaris, systemic lupus
> > > erythematosus, and IgA and gold nephropathies.
> > > 6. Direct morphologic evidence of increased oxidative stress on the
> > > cell membrane is shown by the fact that we have found membrane
> > > deformities in up to 80% of erythrocytes in blood from chronic
> > > fatigue
> > > syndrome patients.
> > > These deformities are quickly reversed by administering ascorbic acid
> > > intravenously.
> > > 7. Changes in electromyopotentials observed in chronic fatigue
> > > patients are consistent with intracellular ionic and membrane
> > > changes.
> > > 8. Clinical entities commonly associated with chronic
> > > fatigue are known to increase oxidative molecular stress.
> > > 9. Clinical evidence obtained with relief of fatigue and related
> > > muscle symptoms with the use of oral and intravenous antioxidant
> > > nutrient therapy.
> > > From a clinical standpoint, this model for the molecular basis of
> > > chronic fatigue is useful for making therapeutic decisions for
> > > successful management of chronic fatigue without drug regimens.
> > > ---------------
>
> > > "Restriction of iron may have positive effects on health in general
> > > and aging in particular"
>
> > > Galaris D, Mantzaris M, Amorgianiotis C
> > > Oxidative stress and aging: the potential role of iron. [Journal
> > > Article]
> > > Hormones (Athens) 2008 Apr-Jun; 7(2):114-22.
>
> > > According to the free radical theory of aging proposed by Denham
> > > Harman more than 50 years ago, oxidatively modified cellular
> > > components accumulate continuously in the cells during the organism's
> > > lifespan leading to progressive decline of cellular functions. Since
> > > then, it has been shown that proteins, lipids, nucleic acids and
> > > other
> > > cell components undergo reversible and/or irreversible oxidative
> > > modifications during aging. Moreover, oxidized cell components can
> > > undergo further oxidative modifications leading to formation of
> > > products that cell degradation systems are incapable of removing.
> > > Accumulation of such non-degradable aggregates further inhibits the
> > > functionality of degradation systems, thus aggravating the effects
> > > and
> > > leading to a vicious cycle. In this presentation, we propose that the
> > > availability of intracellular iron in its redox active form (labile
> > > iron) represents the main catalyst that mediates extensive oxidative
> > > modifications of cellular components and ultimately leads to their
> > > accumulation and consequent cellular dysfunction. It is tempting to
> > > speculate that regulated restriction of labile iron may have positive
> > > effects on health in general and aging in particular.
> > > Hormones (Athens, Greece) [Hormones (Athens)]
> > > ---------------------------------------------------------------------------­­­-----
>
> > > Who loves ya.
> > > Tom
>
> > > Jesus Was A Vegetarian! http :// tinyurl,com /2r2nkh
>
> > > Man Is A Herbivore! http :// tinyurl,com /a3cc3-Hide quoted text -
>
> > - Show quoted text -

Re: Vitamin C for Management Of Chronic Fatigue

On May 18, 5:22 pm, Michael B <baugh...@bellsouth,net > wrote:Take the
vitamin C to reduce the effect of oxidative stress.<<

"Vitamin C, like any drug, can have serious side effects. For
vitamin
C, these effects appear more frequently in people who have iron
overload (e.g., hemochromatosis or multiple transfusions) or who use
unneeded iron supplements."


Greg Froehlich, MD
White River Junction, VT
-------------------------------

Go ahead ..

Tell everyone to take vitamin C ..

Make sure you tell them to tell the pharmacist they are diabetic ..
that way the fits won't cause any kind of a 'stir' at the
checkoutcounter ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http :// tinyurl,com /2r2nkh


Man Is A Herbivore!
http :// tinyurl,com /a3cc3


DEAD PEOPLE WALKING
http :// tinyurl,com /zk9fk






> Oh, John, I just SO ENJOY working with you. Gives me that warm
> fuzzy feeling. Know what I mean?
> Naah, I don't tell the ones with aplastic anemia to take iron, I
> remind
> them that YOUR cited commentary told about reversal of erythrocyte
> damage from the oxidative stress with use of intravenous Vitamin C.
>
> You DO read these things before you post them, don't you? I'd hate to
> think a Health Research Analyst such as yourself would just post
> something without noting such an obvious suggestion towards dealing
> with the damage of oxidative stress. Of course, it isn't like it's a
> new
> revelation, Vitamin C is used to reduce radiation injury, too.
>
> But, hey, now that I'm your partner on this, what do you mean by
> "> Who cares whether he cures them with vitamin C or not.
>
> > The postulation IS .. oxidative stress leading to chronic fatigue."
>
> You're the one telling people how to manage Chronic Fatigue. And
> you have done it by reminding them that IV Vitamin C corrected the
> tissue deformities.
>
> GOOD FOR YOU!!. Isn't he great? He gave a better alternative than
> becoming a grass-eater. Take the vitamin C to reduce the effect of
> oxidative stress.
>
> John, what a stroke of genius on your part. Or was it just a stroke?
>
> On May 18, 7:51 pm, "ironjust...@aol,com " <ironjust...@aol,com > wrote:
>
>
>
> > On May 18, 4:32 pm, Michael B <baugh...@bellsouth,net > wrote:
> >  Isn't this the same stuff posted at the beginning of the thread? <<
>
> > You have a reason to BE .. on this thread .. do ya .. ?
>
> > You tell people with aplastic anemia to take .. iron ..
>
> > I place one of many studies which show this NOT to be a good thing in
> > people with aplastic anemia / transfusions.
>
> > Sooo .. your medical advice is wanting.
>
> > Try not to give medical advice.
>
> > You may go to jail or lose your posting privileges ..
>
> > YOU .. medical advice.. ?
>
> > Heh .. heh ..
>
> > On May 18, 4:32 pm, Michael B <baugh...@bellsouth,net > wrote: Why, by
> > golly, it sure is. And the note in item #6 how the erythrocyte
> >  deformities were quickly reversed with intravenous administration of
> >  Vitamin C. It's still there, telling how to deal with the oxidative
> >  stress postulated by the author you've noted. Just wanted to help you
> > with your crusade. <<
>
> > Help .. ?
>
> > Who you trying to fool .. ?
>
> > Postulated means .. guessing .. he wasn't guess .. he say they were
> > "quickly reversed".
> > You consider that to BE .. postulation .. do ya .. ?
>
> > Who cares whether he cures them with vitamin C or not.
> > The postulation IS .. oxidative stress leading to chronic fatigue.
> > You gonna inject some vitamin C are ya .. ?
> > How you going to manage to DO .. that .. ?
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian! http :// tinyurl,com /2r2nkh
>
> > Man Is A Herbivore! http :// tinyurl,com /a3cc3
>
> > DEAD PEOPLE WALKING http :// tinyurl,com /zk9fk
>
> > > On May 18, 7:20 pm, "ironjust...@aol,com " <ironjust...@aol,com > wrote:
>
> > > > http :// www .majidali,com /Hypothesis.htm
>
> > > > Majid Ali, M.D.
>
> > > > ABSTRACT:
> > > > A hypothesis is proposed that chronic fatigue is a state of
> > > > accelerated oxidative molecular injury.
> > > > Evidence supporting the hypothesis includes the following:
> > > > 1. Spontaneity of oxidation in nature is the basic cause of the aging
> > > > process for organisms capable of aerobic respiration.
> > > > Redox dysregulations represent the initial events that lead to
> > > > clinical disease processes.
> > > > 2. Incidence of chronic fatigue is increasing, as is the oxidant
> > > > stress in the Earth's atmosphere.
> > > > 3. Evidence for oxidative cell membrane injury in chronic fatigue is
> > > > furnished by changes in intracellular and extracellular ions.
> > > > 4. Immunologic abnormalities that occur in chronic fatigue
> > > > are consistent with initial oxidative injury.
> > > > 5. Commonality of association of antigens of HLA-DR3 region with
> > > > chronic fatigue syndrome and with other immune disorders such as
> > > > rheumatoid arthritis, pemphigus vulgaris, systemic lupus
> > > > erythematosus, and IgA and gold nephropathies.
> > > > 6. Direct morphologic evidence of increased oxidative stress on the
> > > > cell membrane is shown by the fact that we have found membrane
> > > > deformities in up to 80% of erythrocytes in blood from chronic
> > > > fatigue
> > > > syndrome patients.
> > > > These deformities are quickly reversed by administering ascorbic acid
> > > > intravenously.
> > > > 7. Changes in electromyopotentials observed in chronic fatigue
> > > > patients are consistent with intracellular ionic and membrane
> > > > changes.
> > > > 8. Clinical entities commonly associated with chronic
> > > > fatigue are known to increase oxidative molecular stress.
> > > > 9. Clinical evidence obtained with relief of fatigue and related
> > > > muscle symptoms with the use of oral and intravenous antioxidant
> > > > nutrient therapy.
> > > > From a clinical standpoint, this model for the molecular basis of
> > > > chronic fatigue is useful for making therapeutic decisions for
> > > > successful management of chronic fatigue without drug regimens.
> > > > ---------------
>
> > > > "Restriction of iron may have positive effects on health in general
> > > > and aging in particular"
>
> > > > Galaris D, Mantzaris M, Amorgianiotis C
> > > > Oxidative stress and aging: the potential role of iron. [Journal
> > > > Article]
> > > > Hormones (Athens) 2008 Apr-Jun; 7(2):114-22.
>
> > > > According to the free radical theory of aging proposed by Denham
> > > > Harman more than 50 years ago, oxidatively modified cellular
> > > > components accumulate continuously in the cells during the organism's
> > > > lifespan leading to progressive decline of cellular functions. Since
> > > > then, it has been shown that proteins, lipids, nucleic acids and
> > > > other
> > > > cell components undergo reversible and/or irreversible oxidative
> > > > modifications during aging. Moreover, oxidized cell components can
> > > > undergo further oxidative modifications leading to formation of
> > > > products that cell degradation systems are incapable of removing.
> > > > Accumulation of such non-degradable aggregates further inhibits the
> > > > functionality of degradation systems, thus aggravating the effects
> > > > and
> > > > leading to a vicious cycle. In this presentation, we propose that the
> > > > availability of intracellular iron in its redox active form (labile
> > > > iron) represents the main catalyst that mediates extensive oxidative
> > > > modifications of cellular components and ultimately leads to their
> > > > accumulation and consequent cellular dysfunction. It is tempting to
> > > > speculate that regulated restriction of labile iron may have positive
> > > > effects on health in general and aging in particular.
> > > > Hormones (Athens, Greece) [Hormones (Athens)]
> > > > ---------------------------------------------------------------------------­­­­-----
>
> > > > Who loves ya.
> > > > Tom
>
> > > > Jesus Was A Vegetarian! http :// tinyurl,com /2r2nkh
>
> > > > Man Is A Herbivore! http :// tinyurl,com /a3cc3-Hidequoted text -
>
> > > - Show quoted text -- Hide quoted text -
>
> - Show quoted text -

Re: Vitamin C for Management Of Chronic Fatigue

Diabetics are a specific population that may not benefit from
vitamin C dose rates of over 250mg/day. And if the pharmacist
is doing the job in an appropriate fashion, the administration will
likely be suggested at divided doses of 50mg each.

Sure glad you still love me, John. But certainly not in a Biblical
way.

On May 18, 8:51 pm, "ironjust...@aol,com " <ironjust...@aol,com > wrote:
>
> Go ahead ..
>
> Tell everyone to take vitamin C ..
>
> Make sure you tell them to tell the pharmacist they are diabetic ..
> that way the fits won't cause any kind of a 'stir' at the
> checkoutcounter ..
>
> Who loves ya.
> Tom

Re: Vitamin C for Management Of Chronic Fatigue

If vitamin C was a "drug" the FDA would regulate it!

I'm off to have an orange now LOL

CB
<ironjustice@aol,com > wrote in message
news:43dadc06-ab4c-4b77-b8d6-dbbcbf2fa0a5@w7g2000hsa.googlegroups,com ...
On May 18, 5:22 pm, Michael B <baugh...@bellsouth,net > wrote:Take the
vitamin C to reduce the effect of oxidative stress.<<

"Vitamin C, like any drug, can have serious side effects. For
vitamin
C, these effects appear more frequently in people who have iron
overload (e.g., hemochromatosis or multiple transfusions) or who use
unneeded iron supplements."


Greg Froehlich, MD
White River Junction, VT
-------------------------------

Go ahead ..

Tell everyone to take vitamin C ..

Make sure you tell them to tell the pharmacist they are diabetic ..
that way the fits won't cause any kind of a 'stir' at the
checkoutcounter ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http :// tinyurl,com /2r2nkh


Man Is A Herbivore!
http :// tinyurl,com /a3cc3


DEAD PEOPLE WALKING
http :// tinyurl,com /zk9fk






> Oh, John, I just SO ENJOY working with you. Gives me that warm
> fuzzy feeling. Know what I mean?
> Naah, I don't tell the ones with aplastic anemia to take iron, I
> remind
> them that YOUR cited commentary told about reversal of erythrocyte
> damage from the oxidative stress with use of intravenous Vitamin C.
>
> You DO read these things before you post them, don't you? I'd hate to
> think a Health Research Analyst such as yourself would just post
> something without noting such an obvious suggestion towards dealing
> with the damage of oxidative stress. Of course, it isn't like it's a
> new
> revelation, Vitamin C is used to reduce radiation injury, too.
>
> But, hey, now that I'm your partner on this, what do you mean by
> "> Who cares whether he cures them with vitamin C or not.
>
> > The postulation IS .. oxidative stress leading to chronic fatigue."
>
> You're the one telling people how to manage Chronic Fatigue. And
> you have done it by reminding them that IV Vitamin C corrected the
> tissue deformities.
>
> GOOD FOR YOU!!. Isn't he great? He gave a better alternative than
> becoming a grass-eater. Take the vitamin C to reduce the effect of
> oxidative stress.
>
> John, what a stroke of genius on your part. Or was it just a stroke?
>
> On May 18, 7:51 pm, "ironjust...@aol,com " <ironjust...@aol,com > wrote:
>
>
>
> > On May 18, 4:32 pm, Michael B <baugh...@bellsouth,net > wrote:
> > Isn't this the same stuff posted at the beginning of the thread? <<
>
> > You have a reason to BE .. on this thread .. do ya .. ?
>
> > You tell people with aplastic anemia to take .. iron ..
>
> > I place one of many studies which show this NOT to be a good thing in
> > people with aplastic anemia / transfusions.
>
> > Sooo .. your medical advice is wanting.
>
> > Try not to give medical advice.
>
> > You may go to jail or lose your posting privileges ..
>
> > YOU .. medical advice.. ?
>
> > Heh .. heh ..
>
> > On May 18, 4:32 pm, Michael B <baugh...@bellsouth,net > wrote: Why, by
> > golly, it sure is. And the note in item #6 how the erythrocyte
> > deformities were quickly reversed with intravenous administration of
> > Vitamin C. It's still there, telling how to deal with the oxidative
> > stress postulated by the author you've noted. Just wanted to help you
> > with your crusade. <<
>
> > Help .. ?
>
> > Who you trying to fool .. ?
>
> > Postulated means .. guessing .. he wasn't guess .. he say they were
> > "quickly reversed".
> > You consider that to BE .. postulation .. do ya .. ?
>
> > Who cares whether he cures them with vitamin C or not.
> > The postulation IS .. oxidative stress leading to chronic fatigue.
> > You gonna inject some vitamin C are ya .. ?
> > How you going to manage to DO .. that .. ?
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian! http :// tinyurl,com /2r2nkh
>
> > Man Is A Herbivore! http :// tinyurl,com /a3cc3
>
> > DEAD PEOPLE WALKING http :// tinyurl,com /zk9fk
>
> > > On May 18, 7:20 pm, "ironjust...@aol,com " <ironjust...@aol,com > wrote:
>
> > > > http :// www .majidali,com /Hypothesis.htm
>
> > > > Majid Ali, M.D.
>
> > > > ABSTRACT:
> > > > A hypothesis is proposed that chronic fatigue is a state of
> > > > accelerated oxidative molecular injury.
> > > > Evidence supporting the hypothesis includes the following:
> > > > 1. Spontaneity of oxidation in nature is the basic cause of the
> > > > aging
> > > > process for organisms capable of aerobic respiration.
> > > > Redox dysregulations represent the initial events that lead to
> > > > clinical disease processes.
> > > > 2. Incidence of chronic fatigue is increasing, as is the oxidant
> > > > stress in the Earth's atmosphere.
> > > > 3. Evidence for oxidative cell membrane injury in chronic fatigue is
> > > > furnished by changes in intracellular and extracellular ions.
> > > > 4. Immunologic abnormalities that occur in chronic fatigue
> > > > are consistent with initial oxidative injury.
> > > > 5. Commonality of association of antigens of HLA-DR3 region with
> > > > chronic fatigue syndrome and with other immune disorders such as
> > > > rheumatoid arthritis, pemphigus vulgaris, systemic lupus
> > > > erythematosus, and IgA and gold nephropathies.
> > > > 6. Direct morphologic evidence of increased oxidative stress on the
> > > > cell membrane is shown by the fact that we have found membrane
> > > > deformities in up to 80% of erythrocytes in blood from chronic
> > > > fatigue
> > > > syndrome patients.
> > > > These deformities are quickly reversed by administering ascorbic
> > > > acid
> > > > intravenously.
> > > > 7. Changes in electromyopotentials observed in chronic fatigue
> > > > patients are consistent with intracellular ionic and membrane
> > > > changes.
> > > > 8. Clinical entities commonly associated with chronic
> > > > fatigue are known to increase oxidative molecular stress.
> > > > 9. Clinical evidence obtained with relief of fatigue and related
> > > > muscle symptoms with the use of oral and intravenous antioxidant
> > > > nutrient therapy.
> > > > From a clinical standpoint, this model for the molecular basis of
> > > > chronic fatigue is useful for making therapeutic decisions for
> > > > successful management of chronic fatigue without drug regimens.
> > > > ---------------
>
> > > > "Restriction of iron may have positive effects on health in general
> > > > and aging in particular"
>
> > > > Galaris D, Mantzaris M, Amorgianiotis C
> > > > Oxidative stress and aging: the potential role of iron. [Journal
> > > > Article]
> > > > Hormones (Athens) 2008 Apr-Jun; 7(2):114-22.
>
> > > > According to the free radical theory of aging proposed by Denham
> > > > Harman more than 50 years ago, oxidatively modified cellular
> > > > components accumulate continuously in the cells during the
> > > > organism's
> > > > lifespan leading to progressive decline of cellular functions. Since
> > > > then, it has been shown that proteins, lipids, nucleic acids and
> > > > other
> > > > cell components undergo reversible and/or irreversible oxidative
> > > > modifications during aging. Moreover, oxidized cell components can
> > > > undergo further oxidative modifications leading to formation of
> > > > products that cell degradation systems are incapable of removing.
> > > > Accumulation of such non-degradable aggregates further inhibits the
> > > > functionality of degradation systems, thus aggravating the effects
> > > > and
> > > > leading to a vicious cycle. In this presentation, we propose that
> > > > the
> > > > availability of intracellular iron in its redox active form (labile
> > > > iron) represents the main catalyst that mediates extensive oxidative
> > > > modifications of cellular components and ultimately leads to their
> > > > accumulation and consequent cellular dysfunction. It is tempting to
> > > > speculate that regulated restriction of labile iron may have
> > > > positive
> > > > effects on health in general and aging in particular.
> > > > Hormones (Athens, Greece) [Hormones (Athens)]
> > > > ---------------------------------------------------------------------------­­­­-----
>
> > > > Who loves ya.
> > > > Tom
>
> > > > Jesus Was A Vegetarian! http :// tinyurl,com /2r2nkh
>
> > > > Man Is A Herbivore! http :// tinyurl,com /a3cc3-Hidequoted text -
>
> > > - Show quoted text -- Hide quoted text -
>
> - Show quoted text -

Re: Vitamin C for Management Of Chronic Fatigue

Michael B wrote:
> See, I'm not even telling you about the Kreb Cycle, and its need for
> Vitamin C for energy production (it is after all called the citric
> acid cycle)

Wow! Ascorbic acid in energy metabolism? What'll they think of next?

--
Marshall Price of Miami
Known to Yahoo as d021317c