Re: Atherosclerosis In COPDOn Apr 25, 6:57=C2=A0am, "ironjust...@aol,com " <ironjust...@aol,com > wrote:
Increased breath with bloodletting.<<
<<snip>>
Post-phlebotomy the maximal oxygen consumption increased from 1.09 +/-
0.34
L/min to 1.26 +/- 0.43 L/min (p less than 0.05) and the maximum
workload
increased from 56.5 +/- 32.6 watts to 74.5 +/- 23.4 watts (p less
than
0.05).
<<snip>>
Chest 1990 Nov;98(5):1073-7 Related Articles, Links
Exercise performance of polycythemic chronic obstructive pulmonary
disease
patients. Effect of phlebotomies.
Chetty KG, Light RW, Stansbury DW, Milne N.
Department of Medicine, VA Medical Center, Long Beach, CA 90822.
The purpose of this study was to determine the effects of phlebotomy
on the
exercise tolerance and right and left ventricular ejection fraction
of
polycythemic patients with chronic obstructive pulmonary disease. Ten
patients with COPD (mean FEV1 =3D 1.32 +/- 0.55 L) and polycythemia
(mean Hct
=3D 62 +/- 3 percent) were studied before and after their hematocrits
had been
reduced to approximately 50 percent. Post-phlebotomy the maximal
oxygen
consumption increased from 1.09 +/- 0.34 L/min to 1.26 +/- 0.43 L/min
(p
less than 0.05) and the maximum workload increased from 56.5 +/- 32.6
watts
to 74.5 +/- 23.4 watts (p less than 0.05). The increase in the
exercise
tolerance appeared to be primarily due to an increased cardiac output
at
Emax. There was no relationship between the increases in the upright
exercise capacity and changes in the supine ejection fractions of the
right
or left ventricular either at rest or during exercise.
PMID: 2225946 [PubMed - indexed for MEDLINE]
---------------------------------------------------------------------------=
=C2=AD-
----
<<snip>>
Significant increase in exercise tolerance and maximal oxygen uptake
at peak
exercise, with significant reduction in mean systemic BP, were
demonstrated
<<snip>>
1: J Thorac Imaging 1990 Jul;5(3):68-72 Related Articles, Links
Exercise-induced changes in left ventricular function after phlebotomy
in
patients with polycythemic COPD.
Milne N, Light RW, Chetty KG.
Nuclear Medicine Service, Veterans Affairs Medical Center, Long
Beach,
California 90822.
The exercise capacity of polycythemic COPD patients has been shown to
improve after phlebotomy, possibly because of reduction of
ventricular
afterload by decreased blood viscosity, resulting in increased
cardiac
output. Ten patients with polycythemic COPD and mean hematocrit 62%
were
studied at rest and during exercise before and after reduction of
mean
hematocrit to 50% by repeated phlebotomy. Pulmonary function was
evaluated
by physiologic exercise testing on a bicycle ergometer. Cardiac
function was
evaluated by rest and exercise RNVG. Significant increase in exercise
tolerance and maximal oxygen uptake at peak exercise, with
significant
reduction in mean systemic BP, were demonstrated. Ejection fractions
did not
change, but dV/dt for ejection from the left ventricle at peak
exercise
improved significantly. Mean SV counts, ESV counts, and EDV counts
were
measured and the fractional increase with exercise compared for
prephlebotomy and postphlebotomy, assuming that resting volumes would
not
change. ESV counts and EDV counts were both proportionately, though
not
significantly, reduced postphlebotomy. The data tend to support the
hypothesis that the afterload on the left ventricle is reduced, with
resulting improved myocardial contractility and left ventricular
function.
Improved peripheral oxygen uptake may also be a factor.
PMID: 2362307 [PubMed - indexed for MEDLINE]
This is the medical professions .. alternative to phlebotomy .
Drugs ..
theophylline ..
Theophylline lowers the red blood cells .. it halts the production of
erythropoietin .. and THAT halts the production of red blood cells..
leaving
=2E. fewer red blood cells.
Voila .. glorified .. phlebotomy
1: Arch Intern Med 1997 Jul 14;157(13):1474-8 Related Articles, Links
Effect of theophylline on erythrocytosis in chronic obstructive
pulmonary
disease.
Oren R, Beeri M, Hubert A, Kramer MR, Matzner Y.
Department of Internal Medicine, Hadassah University Hospital, Mount
Scopas,
Israel.
BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD)
tend
to develop secondary erythrocytosis to compensate for their chronic
hypoxia.
Theophylline has recently been shown to reduce hematocrit and
erythropoietin
blood levels in normal subjects and in patients with erythrocytosis
after
renal transplantation. OBJECTIVE: To determine whether theophylline
may be
used to lower the hematocrit in patients with COPD. METHODS: Two
hundred
four patients with COPD were studied retrospectively and 10 patients
prospectively (8 starting treatment with the drug [group 1] and 2 who
suspended its long-term use [group 2]) for the correlation between
theophylline therapy and hematocrit and erythropoietin level. RESULTS:
In
the patients studied retrospectively, lower hematocrits were found in
the
theophylline-treated than in the untreated patients (0.43 +/- 0.006 vs
0.46
+/- 0.007, respectively; P < .002). Twelve untreated patients and 2 of
those
treated with theophylline had hematocrits above 52%. Oxygen
saturation
levels were similar in both groups, and exclusion of patients with
oxygen
saturation lower than 88% did not change the pattern, suggesting that
the
effect of theophylline could not be entirely explained by improved
oxygen
availability. Seven of the 8 patients studied prospectively in group 1
(P <
=2E02) and the 2 patients in group 2 showed inverse correlations
between
hematocrits and theophylline administration. A similar pattern was
observed
with serum erythropoietin levels in 5 of 7 patients studied. The
effects
were reproducible on rechallenge in 3 of the 4 patients in group 1 and
the 2
patients in group 2. CONCLUSIONS: Theophylline may have a beneficial
effect
in treatment and prevention of erythrocytosis in patients with COPD.
PMID: 9224226 [PubMed - indexed for MEDLINE]
Who loves ya.
Tom
Jesus Was A Vegetarian!
http :// tinyurl,com /2r2nkh
Man Is A Herbivore!
http :// tinyurl,com /a3cc3
DEAD PEOPLE WALKING
http :// tinyurl,com /zk9fk
> They don't listen to logic. IE: Increased breath with bloodletting.
>
> Maybe they'll listen to Science.
>
> This would be the .. rationale ..
>
> Increased Arterial Stiffness Common in COPD Patients
>
> NEW YORK (Reuters Health) Apr 23 - Chronic obstructive pulmonary
> disease (COPD) is associated with increased arterial stiffness and
> elevated blood pressure, which may explain the excess cardiovascular
> morbidity and mortality in this patient population, note researchers
> from the UK in the April issue of the journal Thorax.
>
> The reasons why patients with COPD are at high risk of having a heart
> attack or stroke compared to the general population "are not clear,"
> Dr. Joy J. Miller, from Borders General Hospital and the University of
> Edinburgh, noted in comments to Reuters Health.
>
> She and her colleagues measured blood pressure and blood vessel
> stiffness in 102 COPD patients and 103 carefully matched healthy
> persons with similar smoking histories and found that COPD patients
> had stiffer blood vessels and higher blood pressures than controls.
>
> "This suggests that COPD is not simply a disease of the lungs but
> involves other systems including the heart and vasculature," Dr.
> Miller said.
>
> Compared to healthy controls, COPD patients had elevated augmentation
> pressure (p =3D 0.005) and a reduced time to wave reflection (p =3D 0.004)=
> and these differences were associated with increases in both diastolic
> (p =3D 0.005) and systolic (p < 0.001) blood pressure.
>
> Moreover, serum C-reactive protein levels were threefold higher in
> COPD patients than in control patients.
>
> Dr. Miller noted that "two thirds of our COPD patients had high blood
> pressure, and the majority of them were not on any treatment for this.
> Our study highlights the need for careful assessment of cardiovascular
> risk in COPD patients."
>
> "The use of simple effective treatments to lower blood pressure has
> the potential to prevent excess heart attacks and strokes in COPD
> patients," she concluded.
>
> Thorax 2008;63:306-311.
> ---------------------------
>
> Blood donation, body iron status and carotid intima-media thickness
>
> Author(s): Engberink, M.F.; Geleijnse, J.M.; Durga, J.; Swinkels,
> D.W.; Kort, W.L.A.M. de; Schouten, E.G.; Verhoef, P.
> Source: Atherosclerosis 196 (2008)2. - ISSN 0021-9150 - p. 856 - 862.
> Department(s): Afdeling Humane voeding (Division of Human Nutrition)
> Research programme(s): Graduate School VLAG (2004 - 2010 )
> Subtheme: =E2=90=96D. Nutrition, metabolism and health
> Type of publication: Article in refereed journal
> Year of publication: 2008
> Abstract:
> Iron could promote free radical formation, which may lead to injury
> of
> the arterial wall and atherosclerosis.
> Blood donation may reduce cardiovascular risk by lowering body iron
> status.
> We collected data on blood donation history and intima-media
> thickness
> of the common carotid artery (CIMT) in 819 subjects (50-70 years),
> who
> were recruited from municipal and blood bank registries in The
> Netherlands.
> Serum iron parameters were assessed, including non-transferrin bound
> iron (NTBI) that has recently been found in conditions of iron
> overload.
> Serum ferritin was lower in current donors (n=3D443; 44mug/L) than in
> ex-
> donors (n=3D120; 114mug/L) and never-donors (n=3D256; 124mug/L, P for
> trend <0.001).
> For NTBI, values were 2.33, 2.54, and 2.51mumol/L, respectively
> (P<0.05). CIMT was slightly reduced in frequent donors (i.e., >/=3D49
> times during life or >/=3D2 times per year), although not statistically
> significant.
> CIMT was not significantly related to NTBI.
> Frequent blood donation, resulting in lowered body iron, might give
> some protection against accelerated atherosclerosis.
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! http :// tinyurl,com /2r2nkh
>
> Man Is A Herbivore! http :// tinyurl,com /a3cc3
>
> DEAD PEOPLE WALKING http :// tinyurl,com /zk9fk