Re: Bloodletting And DiabetesOn May 14, 10:27=A0pm, "ironjust...@aol . com " <ironjust...@aol . com >
wrote:Linus Pauling and his work with what he believed to be very
high levels of oxidative stress/ rust / free radicals / reactive
oxygen species / lack of antioxidants. <<
This would be a human model of increased oxidation in the body.
American Journal of Clinical Nutrition, Vol. 81, No. 1, 95-103,
January 2005
=A9 2005 American Society for Clinical Nutrition
----------------------------------------------------------------------------=
----
ORIGINAL RESEARCH COMMUNICATION
-Tocopherol disappearance is faster in cigarette smokers and is
inversely related to their ascorbic acid status1,2,3
Richard S Bruno, Rajasekhar Ramakrishnan, Thomas J Montine, Tammy M
Bray and Maret G Traber
1 From the Department of Human Nutrition, The Ohio State University,
Columbus, OH (RSB); the Linus Pauling Institute, Oregon State
University, Corvallis, OR (RSB, TMB, and MGT); the College of
Physicians and Surgeons, Columbia University, New York (RR); the
Department of Pathology, University of Washington, Seattle (TJM)
2 Supported by grants to MGT (NIH DK59576) and TJM (AG05144 and
AG16835). The Natural Source Vitamin E Association provided partial
support for the purchase of the LC-MS and provided the deuterium-
labeled -tocopheryl acetate supplements. Tocopherol standards
including d0- (unlabeled), d6-RRR, and d3-all-rac--tocopheryl acetates
and unlabeled d0--tocopherol were gifts from James Clark (Cognis
Nutrition and Health, LaGrange, IL); all-rac--5,7,8-(CD3)3-tocopheryl
acetate (d9-all-rac--tocopheryl acetate) was provided by Carolyn Good
(General Mills) and was synthesized by Isotec Inc (Miamisburg, OH).
3 Address reprint requests to MG Traber, 561A Weniger Hall, Linus
Pauling Institute, Oregon State University, Corvallis, OR 97331. E-
mail: maret.traber@oregonstate.edu.
Background: Cigarette smokers have enhanced oxidative stress from
cigarette smoke exposure and from their increased inflammatory
responses.
Objective: The objective of this study was to determine whether
cigarette smoking increases plasma -tocopherol disappearance in
otherwise healthy humans.
Design: Smokers and nonsmokers (n =3D 10/group) were supplemented with
deuterium-labeled -tocopheryl acetates (75 mg each of d3-RRR--
tocopheryl acetate and d6-all-rac--tocopherols acetate) for 6 evenings
(days =966 to =961). Plasma -tocopherols, ascorbic acid, uric acid, and F2-
isoprostanes were measured in blood samples collected on days =966
through 17. The urinary -tocopherol metabolite, -carboxy-ethyl-hydroxy-
chroman (-CEHC), was measured on days =966, 0, and 17 in 24-h urine
samples.
Results: F2-isoprostanes were, on average, 40% higher in smokers than
in nonsmokers. On day 0, plasma labeled and unlabeled -tocopherol
concentrations were not significantly different between groups.
Smoking resulted in faster fractional disappearance of plasma -
tocopherol (0.215 =B1 0.011 compared with 0.191 =B1 0.009 pools/d; P <
0.05). Fractional disappearance rates of -tocopherol correlated with
plasma ascorbic acid concentrations in smokers (P =3D 0.021) but not in
nonsmokers despite plasma ascorbic acid concentrations that were not
significantly different between groups. By day 17, cigarette smoking
resulted in lower plasma -tocopherol concentrations and urinary
excretion of labeled and unlabeled -CEHC (P < 0.05).
Conclusions: Cigarette smoking increased -tocopherol disappearance.
Greater rates of -tocopherol disappearance in smokers appear to be
related to increased oxidative stress accompanied by lower plasma
ascorbic acid concentrations. Thus, smokers have an increased
requirement for both -tocopherol and ascorbic acid.
Key Words: Oxidative stress =95 vitamin E =95 vitamin C =95 cigarette smoke
=95 antioxidants =95 dietary requirements
Who loves ya.
Tom
Jesus Was A Vegetarian!
* tinyurl . com /2r2nkh
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
> On May 13, 10:04=A0pm, "nanny" <gloria...@woh.rr . com > wrote:
> =A0So, has anyone asked him why he's hung up on iron in particular? =A0<<
>
> Hard work.
>
> On May 13, 10:04 pm, "nanny" <gloria...@woh.rr . com > wrote:I'll ask:
> Tom, why are you obsessed with iron over any other health issue? <<
>
> Years ago Linus Pauling and his work with what he believed to be very
> high levels of oxidative stress/ rust / free radicals / reactive
> oxygen species / lack of antioxidants.
>
> His work was and is still accepted as very good work.
>
> Linus Pauling was a double Nobel prize winner.
>
> Years later I was flipping through a People magazine at my
> physiotherapists office and ran across a mans' hypothesis.
> His hypothesis is "the iron from meat builds progressively in the body
> leading to high levels of rust / oxidative stress."
>
> That clicked in my mind as an explanation for the high level of
> oxidative stress and this clue led me into the last few years of work.
>
> Here we are today fifteen years later and iron reduction therapy /
> phlebotomy has JUST been proposed FOR literally everyone.
>
> Just like I've been proposing.
>
> Evidently it seems I'm right.
>
> Using .."how do you feel" ..as a marker.
>
> "These results justify iron depletion"
>
> * care.diabetesjournals.org/cgi/content/extract/31/3/e18
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! * tinyurl . com /2r2nkh
>
> Man Is A Herbivore! * tinyurl . com /a3cc3
>
> DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
>
>
> Nanny"dar" <darh...@gmail . com > wrote in message
>
> >news:ca9513fe-57b8-4a6c-8915-96739e80b4e6@y21g2000hsf.googlegroups . com ...=
> > On May 12, 3:16 am, "Manky Badger" <you.m...@be.joking> wrote:
>
> > > "Michael B" <baugh...@bellsouth . net > wrote in message
>
> > >news:f3dc750e-f644-47cb-8e8b-05ce5a1068c5@59g2000hsb.googlegroups . com ..=
.
>
> > > > Actually, it can't be seen as plagiarized when there is fully citing=
> > > > of source material.
>
> > > > And it can be seen as on-topic for the diabetes group. And for the
> > > > nutrition and pathology groups.
>
> > > Pathology groups? No - not really.
>
> > > > In spite of his one-person parade, there is some value to what he
> > > > says, for some of the readers. If a person doesn't deal well with th=
e
> > > > iron, there can indeed be problems that are not typically attributed=
> > > > to iron overload. Used to happen more when iron skillets were more
> > > > common, with metal spatulas instead of plastic.
>
> > > > Also, it should be considered if a person has had at least 13 blood
> > > > transfusions, not necessarily within a narrow time frame. Several
> > > > years, even, especially for men, pre and postmenopausal women.
>
> > > Read what he's posted carefully. You'll find that there are well known=
> > > side
> > > effects of massive iron overloads, like in the example of multiple blo=
od
> > > transfusions. There are also well know problems of iron metabolism. Al=
l of
> > > which are quite rare in the great scheme of things.
> > > However the Ferrous Fool utterly misunderstands what's going on, and
> > > furthermore rejects all attempts at enlightening him. Instead he prefe=
rs
> > > to
> > > continue his religous crusade by posting any mention of iron onto any
> > > seemingly random newsgroup.
> > > I suspect someone close to him died of one of these rare conditions an=
d
> > > it's
> > > unhinged him somewhat.
>
> > > > But the part that is so annoying about him is the presentation of
> > > > iron overload as the single most relevant factor from diabetes to
> > > > end organ failure in lupus. Certainly not apologizing for him, he
> > > > is a pest at times, but sometimes he presents something of value,
> > > > even if you have to pick through a lot of shit for the piece of corn=
.
>
> > > The only "bits of corn" I've ever found are those things which are
> > > factually
> > > true but posted out of context.
>
> > Manky,
>
> > RE: =A0I suspect someone close to him died of one of these rare
> > conditions and it's
> > unhinged him somewhat.
>
> > Quite honestly, I've often thought that perhaps he's the one that has
> > an iron condition. =A0Perhaps that's why he has such interest.....
>
> > In any event, there has been some articles that I've enjoyed, others I
> > haven't. =A0I'm positive and certain, that he can say the same about
> > me......
>
> > It's like watching tv or listening to music, if you don't want to
> > watch or hear, change the channel. =A0In this case, don't read.....
>
> > Take care and be well out there! =A0Debra- Hide quoted text -
>
> > - Show quoted text -- Hide quoted text -
>
> - Show quoted text -